Vitamin D overload and experimental Trypanosoma cruzi infection: Parasitological and histopathological aspects
| Autor: | Jacques Robert Nicoli, Silva Me, Marcelo Eustáquio Silva, Eduardo Alves Bambirra, Márcio E. Silva, Enio C. Vieira |
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| Rok vydání: | 1993 |
| Předmět: |
Chagas disease
Vitamin Ratón Trypanosoma cruzi Physiology Biology Median lethal dose Drug Administration Schedule Lethal Dose 50 Mice chemistry.chemical_compound medicine Vitamin D and neurology Animals Chagas Disease Vitamin D Mice Inbred BALB C Dose-Response Relationship Drug General Medicine medicine.disease biology.organism_classification Disease Models Animal Dose–response relationship chemistry Immunology Female Trypanosomiasis |
| Zdroj: | Repositório Institucional da UFOP Universidade Federal de Ouro Preto (UFOP) instacron:UFOP |
| ISSN: | 0300-9629 |
| DOI: | 10.1016/0300-9629(93)90026-z |
| Popis: | 1. Six groups of 45-day-old, 23.0 +/- 1.7 g, female Balb/c mice were inoculated intraperitoneally with 63, 252, 440, 630, 2520 or 6300 I.U. of vitamin D for 6 days. A seventh group was inoculated with saline. Each group consisted of 30 animals. 2. All animals inoculated with the doses of 2520 and 6300 and 70% of mice which received 630 I.U. of vitamin D died 21 days after the first administration of the vitamin. The LD50 was 630 I.U. 3. The survivors were divided into two groups inoculated intraperitoneally with 5000 trypomastigotes of either Y or CL strain of Trypanosoma cruzi. 4. Based on the survival index on day 73 after infection, Vitamin D gave statistically significant protection (P < 0.01) for mice inoculated with doses of 63 or 430 I.U. of Y or CL strains, respectively. 5. On histopathological examination, inflammatory reaction and cellular and tissue parasitism were less intense in animals which received higher doses of vitamin D. 6. It is concluded that an overload of vitamin D had a protective effect against CL and Y strains of Trypanosoma cruzi infection in Balb/c mice. |
| Databáze: | OpenAIRE |
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