Rifampicin enhances activity of daptomycin and vancomycin against both a polysaccharide intercellular adhesin (PIA)-dependent and -independent Staphylococcus epidermidis biofilm
| Autor: | Shawn R. Slater, Michael E. Olson, Paul D. Fey, Mark E. Rupp |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Microbiology (medical)
Micrococcaceae medicine.drug_class Virulence Factors Antibiotics Guinea Pigs Microbial Sensitivity Tests Biology Microbiology chemistry.chemical_compound Daptomycin Staphylococcus epidermidis guinea pig model Vancomycin medicine polycyclic compounds Animals Pharmacology (medical) Antibacterial agent Original Research Pharmacology biomaterial infections Polysaccharides Bacterial Lipopeptide Drug Synergism biochemical phenomena metabolism and nutrition biology.organism_classification bacterial infections and mycoses Anti-Bacterial Agents tissue cage Disease Models Animal Infectious Diseases chemistry Biofilms Staphylococcal Skin Infections Rifampin icaADBC operon Rifampicin medicine.drug |
| Zdroj: | Journal of Antimicrobial Chemotherapy |
| ISSN: | 1460-2091 0305-7453 |
| Popis: | Objectives and methods This study addressed the efficacy of daptomycin, vancomycin, rifampicin, daptomycin/rifampicin and vancomycin/rifampicin against a polysaccharide intercellular adhesin (PIA)-dependent and -independent Staphylococcus epidermidis biofilm using flow cell and guinea pig tissue cage models. Results The flow cell model of both PIA-dependent and -independent biofilms demonstrated that the viable cell count after treatment with daptomycin/rifampicin was significantly lower (P Conclusions Interpretation of these data suggests that rifampicin is highly active against S. epidermidis biofilms and both vancomycin and daptomycin are effective at reducing the subpopulation of bacteria that develop rifampicin resistance. |
| Databáze: | OpenAIRE |
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