Squamous cell carcinoma of the urinary bladder: Systematic review of clinical characteristics and therapeutic approaches
| Autor: | Cody Smith, Jeremy W. Martin, Rahul Dutta, Estrella M. Carballido, Ahmed Ahmed, Ramy F. Youssef, Bilal Farhan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Oncology
COX-2 cyclooxygenase 2 NAC neoadjuvant chemotherapy medicine.medical_specialty DFS disease-free survival Lymphovascular invasion Urology medicine.medical_treatment CISC clean intermittent self-catheterisation Bladder 030232 urology & nephrology Review SEER Surveillance Epidemiology and End Results Squamous cell carcinoma (SCC) urologic and male genital diseases SCC squamous cell carcinoma Cystectomy OS overall survival 03 medical and health sciences SCI spinal cord injury 0302 clinical medicine Internal medicine medicine Surveillance Epidemiology and End Results HER-2 human epidermal growth factor receptor 2 RC radical cystectomy neoplasms Lymph node FGF-2 fibroblast growth factor 2 Urinary bladder Radiotherapy business.industry Standard treatment Immunotherapy HPV human papilloma virus NB-SCC non-bilharzial SCC LVI lymphovascular invasion Radiation therapy B-SCC bilharzial-associated SCC stomatognathic diseases PD-L1 programmed death-ligand 1 Radical cystectomy medicine.anatomical_structure 030220 oncology & carcinogenesis LN lymph node business PD-1 programmed cell death 1 Bilharzial |
| Zdroj: | Arab Journal of Urology |
| ISSN: | 2090-5998 2090-598X |
| Popis: | Objective To highlight the current understanding of the epidemiology, clinicopathological characteristics, and management of squamous cell carcinoma (SCC) of the bladder, as it accounts for 2–5% of bladder tumours, with a focus on non-bilharzial-associated SCC (NB-SCC). The standard treatment for bladder SCC remains radical cystectomy (RC). We present an updated clinical profile of bladder SCC and a review of NB-SCC therapeutic approaches, including RC, neoadjuvant and adjuvant treatments, radiotherapy, chemotherapy, and immunotherapy. Methods Using search terms relating to SCC, urinary bladder, and treatment modalities, we performed a search of the PubMed and Embase databases to identify NB-SCC treatment approaches and outcomes. Peer-reviewed English language reports from 1975 to present assessing SCC management were included. Two authors independently screened and extracted the data. Results Of the 806 articles screened, 10 met the pre-defined inclusion criteria. RC was performed in seven of the 10 studies. Although radiotherapy alone yielded poor outcomes, preoperative radiotherapy and RC were associated with improved survival. There is little evidence supporting the use of chemotherapy in NB-SCC, and its efficacy in relation to RC is not known. Conclusion Based on current literature, there is insufficient evidence to provide a treatment recommendation for NB-SCC. Whilst RC is the standard of care, the role of preoperative radiotherapy should be revisited and compared to RC alone. Additional studies incorporating multimodal approaches, contemporary radiation techniques, and systemic therapies are warranted. Immunotherapy as a treatment for bladder SCC has yet to be investigated. |
| Databáze: | OpenAIRE |
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