Some Properties of Erythrocyte Na+-K+-ATPase in Essenial Hypertension
| Autor: | Gurevich Vs, Maslova Mn, Bagrov JYu, Shalabodov Ad, Kazennov Am |
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| Rok vydání: | 1987 |
| Předmět: |
Adult
Male medicine.medical_specialty Erythrocytes Hydrogen potassium ATPase ATPase Allosteric regulation Magnesium Chloride In Vitro Techniques Essential hypertension Internal medicine Internal Medicine medicine Humans Magnesium Na+/K+-ATPase chemistry.chemical_classification biology Erythrocyte Membrane Middle Aged medicine.disease Enzyme assay Enzyme Membrane Endocrinology chemistry Hypertension biology.protein Female Sodium-Potassium-Exchanging ATPase |
| Zdroj: | Clinical and Experimental Hypertension. Part A: Theory and Practice. 9:1221-1232 |
| ISSN: | 0730-0077 |
| DOI: | 10.3109/10641968709160045 |
| Popis: | The activity and some allosteric properties of Na+ -K+ -ATPase in erythrocytes and their membrane preparations (ghosts) from 57 patients with essential hypertension and 36 normotensive controls were studied. To reveal enzyme activity in whole erythrocytes the cells were pretreated with detergent Tween-20. It was found that in the patient erythrocytes the Na+ -K+ -ATPase activity was 33% less as compared to the control group. Moreover, in the patient erythmcytes the sensitivity of the enzyme to high concentrations of MgCI2 was decreased. In contrast, no analogous changes of the enzyme were revealed in the patient ghosts. It is suggested that the erythrocytes of patients with essential hypertension contain an inhibitor of Na+ -K+ -ATPase. |
| Databáze: | OpenAIRE |
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