Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis
| Autor: | Daniel P. Szeto, Michael G. Rosenfeld, Forrest Liu, Chijen R. Lin, Shawn M. O'Connell, Chrissa Kioussi, Juan Carlos Izpisúa-Belmonte, Paola Briata |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Heart Defects
Congenital congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Pituitary gland Mesoderm Activin Receptors Type II Xenopus Morphogenesis Chick Embryo Biology Cell Line stomatognathic system Anterior pituitary Internal medicine medicine Animals Paired Box Transcription Factors Abnormalities Multiple Receptors Growth Factor Lung Body Patterning Homeodomain Proteins Multidisciplinary PITX2 Heart development Chimera Embryogenesis Nuclear Proteins Heart stomatognathic diseases Phenotype Endocrinology medicine.anatomical_structure Pituitary Gland Ectopic expression sense organs Tooth Gene Deletion Transcription Factors |
| Zdroj: | Nature. 401:279-282 |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/45803 |
| Popis: | Pitx1 and Pitx2 are highly homologous, bicoid-related transcription factors. Pitx2 was initially identified as the gene responsible for the human Rieger syndrome, an autosomal dominant condition that causes developmental abnormalities. Pitx2 is asymmetrically expressed in the left lateral-plate mesoderm, and mutant mice with laterality defects show altered patterns of Pitx2 expression that correlate with changes in the visceral symmetry (situs). Ectopic expression of Pitx2 in the right lateral-plate mesoderm alters looping of the heart and gut and reverses body rotation in chick and Xenopus embryos. Here we describe the phenotype of Pitx2 gene-deleted mice, characterized by defective body-wall closure, right pulmonary isomerism, altered cardiac position, arrest in turning and, subsequently, a block in the determination and proliferation events of anterior pituitary gland and tooth organogenesis. Thus, Pitx2 is a transcription factor that encodes 'leftness' of the lung. |
| Databáze: | OpenAIRE |
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