The Italian Dystonia Registry: rationale, design and preliminary findings
| Autor: | Giovanni Defazio, Roberto Ceravolo, Maria Concetta Altavista, Giovanni Fabbrini, Alberto Albanese, Marcello Esposito, Marco Aguggia, Ruggero Bacchin, Maurizio Zibetti, L. Polidori, Maria Rosaria Mazza, Nicola Tambasco, Giovanni Cossu, Antonio Pisani, E Unti, Roberta Arca, Marcello Romano, Paolo Girlanda, Martina Petracca, Maria Cotelli, Michele Tinazzi, Giovanni Abbruzzese, Anna Rita Bentivoglio, Francesca Morgante, Gina Ferrazzano, Roberta Pellicciari, Roberto Eleopra, Laura Bertolasi, Cesa Scaglione, Luca Magistrelli, Angelo Fabio Gigante, Rocco Liguori, Nicola Modugno, Christian Lettieri, Salvatore Misceo, M. Coletti Moja, Alfredo Berardelli, Francesco Bono, Giovanna Squintani, Laura Avanzino, Silvio Peluso |
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| Přispěvatelé: | Defazio, Giovanni, Esposito, M., Abbruzzese, G., Scaglione, C.L., Fabbrini, G., Ferrazzano, G., Peluso, S., Pellicciari, R., Gigante, A.F., Cossu, G., Arca, R., Avanzino, L., Bono, F., Mazza, M.R., Bertolasi, L., Bacchin, R., Eleopra, R., Lettieri, C., Morgante, F., Altavista, M.C., Polidori, L., Liguori, R., Misceo, S., Squintani, G., Tinazzi, M., Ceravolo, R., Unti, E., Magistrelli, L., Coletti Moja, M., Modugno, N., Petracca, M., Tambasco, N., Cotelli, M.S., Aguggia, M., Pisani, A., Romano, M., Zibetti, M., Bentivoglio, A.R., Albanese, A., Girlanda, P., Berardelli, A., Defazio, G., Scaglione, C. L., Gigante, A. F., Mazza, M. R., Altavista, M. C., Cotelli, M. S., Bentivoglio, A. R. |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Pediatrics Movement disorders Epidemiology Severity of Illness Index 0302 clinical medicine Retrospective Studie 80 and over Cervical dystonia Registries Age of Onset Dystonia Aged 80 and over education.field_of_study General Medicine Middle Aged Natural history Risk factors 2708 Neurology (clinical) Psychiatry and Mental Health Italy Cohort Disease Progression Female Settore MED/26 - Neurologia medicine.symptom Human Adult medicine.medical_specialty congenital hereditary and neonatal diseases and abnormalities Blepharospasm Population Aged Humans Retrospective Studies Risk Factors Young Adult Dermatology 03 medical and health sciences medicine otorhinolaryngologic diseases education business.industry medicine.disease nervous system diseases 030104 developmental biology Physical therapy Etiology Risk factor business 030217 neurology & neurosurgery |
| Popis: | The Italian Dystonia Registry is a multicenter data collection system that will prospectively assess the phenomenology and natural history of adult-onset dystonia and will serve as a basis for future etiological, pathophysiological and therapeutic studies. In the first 6 months of activity, 20 movement disorders Italian centres have adhered to the registry and 664 patients have been recruited. Baseline historical information from this cohort provides the first general overview of adult-onset dystonia in Italy. The cohort was characterized by a lower education level than the Italian population, and most patients were employed as artisans, builders, farmers, or unskilled workers. The clinical features of our sample confirmed the peculiar characteristics of adult-onset dystonia, i.e. gender preference, peak age at onset in the sixth decade, predominance of cervical dystonia and blepharospasm over the other focal dystonias, and a tendency to spread to adjacent body parts, The sample also confirmed the association between eye symptoms and blepharospasm, whereas no clear association emerged between extracranial injury and dystonia in a body site. Adult-onset dystonia patients and the Italian population shared similar burden of arterial hypertension, type 2 diabetes, coronary heart disease, dyslipidemia, and hypothyroidism, while hyperthyroidism was more frequent in the dystonia population. Geographic stratification of the study population yielded no major difference in the most clinical and phenomenological features of dystonia. Analysis of baseline information from recruited patients indicates that the Italian Dystonia Registry may be a useful tool to capture the real world clinical practice of physicians that visit dystonia patients. |
| Databáze: | OpenAIRE |
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