Olympic boxing is associated with elevated levels of the neuronal protein tau in plasma
| Autor: | Denise Wilson, Jeffrey Randall, Sanna Neselius, Jan Marcusson, Henrik Zetterberg, Kaj Blennow, Helena Brisby |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Adolescent Traumatic brain injury Neuroscience (miscellaneous) Poison control tau Proteins S100 Calcium Binding Protein beta Subunit Cerebrospinal fluid Cognition Internal medicine Surveys and Questionnaires Concussion Glial Fibrillary Acidic Protein Developmental and Educational Psychology Medicine Blood test Humans Glasgow Coma Scale Nerve Growth Factors Prospective Studies Sweden Amyloid beta-Peptides Glial fibrillary acidic protein biology medicine.diagnostic_test business.industry Brain-Derived Neurotrophic Factor Head injury Diffuse axonal injury S100 Proteins Boxing medicine.disease Endocrinology Brain Injuries biology.protein Educational Status Female Neurology (clinical) business human activities Biomarkers Follow-Up Studies |
| Zdroj: | Brain injury. 27(4) |
| ISSN: | 1362-301X |
| Popis: | OBJECTIVES: The aim of this study was to investigate if olympic (amateur) boxing is associated with elevation of brain injury biomarkers in peripheral blood compared to controls. MATERIALS AND METHODS: Thirty olympic boxers competing in at least 47 bouts were compared to 25 controls. Blood was collected from the controls at one occasion and from the boxers within 1-6 days after a bout and after a rest period of at least 14 days. Tau concentration in plasma was determined using a novel single molecule ELISA assay and S-100B, glial fibrillary acidic protein, brain-derived neurotrophic factor and amyloid β 1-42 were determined using standard immunoassays. RESULTS: None of the boxers had been knocked-out during the bout. Plasma-tau was significantly increased in the boxers after a bout compared to controls (mean ± SD, 2.46 ± 5.10 vs. 0.79 ± 0.961 ng L(-1), p = 0.038). The other brain injury markers did not differ between the groups. Plasma-tau decreased significantly in the boxers after a resting period compared to after a bout (p = 0.030). CONCLUSIONS: Olympic boxing is associated with elevation of tau in plasma. The repetitive minimal head injury in boxing may lead to axonal injuries that can be diagnosed with a blood test. |
| Databáze: | OpenAIRE |
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