Volume-sensitive taurine efflux from mammary tissue is not obliged to utilize volume-activated anion channels
| Autor: | P. Hawkins, M. J. Cliff, David B. Shennan |
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| Rok vydání: | 1996 |
| Předmět: |
Taurine
Biophysics Stimulation Biology Biochemistry Ion Channels Ion chemistry.chemical_compound Mammary Glands Animal Osmotic Pressure Animals Rats Wistar Molecular Biology Cell Size chemistry.chemical_classification Aspartic Acid Mammary tissue Cell Biology Rats Amino acid chemistry DIDS Mefenamate Female Efflux |
| Zdroj: | Bioscience Reports. 16:459-465 |
| ISSN: | 1573-4935 0144-8463 |
| DOI: | 10.1007/bf01198461 |
| Popis: | Cell-swelling, induced by a hyposmotic shock, activates the release of taurine from lactating rat mammary tissue expiants. The degree of stimulation of taurine efflux was dependent upon the extent of cell-swelling. Volume-sensitive taurine release was attenuated by the anion transport inhibitors NPPB, DIOA, DIDS, niflumate, flufenamate, mefenamate and diiodosalicylate but not by salicylate. Cell-swelling, following a hyposmotic challenge, did not increase the unidirectional efflux of radiolabelled I− or D-asparate from mammary tissue expiants. The results suggest that although mammary tissue expresses a volume-sensitive amino acid transport system which is inhibited by anion transport blockers the pathway has no identity with volume-activated anion channels. |
| Databáze: | OpenAIRE |
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