Therapeutic Effect of Resveratrol on Morphine-Induced Damage in Male Reproductive System of Mice by Reducing Nitric Oxide Serum Level
| Autor: | Faramarz Jalili, Cyrus Jalili, Seyran Kakabaraei, Mohammad Reza Salahshoor, Maryam Ahookhash, Ali Ghanbari, Ali Akrami, Maryam Sohrabi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Morphine
business.industry 010401 analytical chemistry Therapeutic effect Resveratrol Pharmacology Nitric Oxide 01 natural sciences 0104 chemical sciences Nitric oxide 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine chemistry 030220 oncology & carcinogenesis medicine Male reproductive system Anatomy business Spermatogenesis medicine.drug |
| Zdroj: | International Journal of Morphology v.35 n.4 2017 SciELO Chile CONICYT Chile instacron:CONICYT |
| Popis: | SUMMARY: Morphine is one of the naturally occurring phenanthrene alkaloids of opium that induces adverse effects on male reproductive system. Resveratrol is a phytoestrogen and antioxidant of red grape. The main goal is to investigate whether resveratrol could inhibit adverse effects of morphine on sperm cell viability, count, motility as well as testis histology, testosterone hormone and nitric oxide levels in mice. In the present study, 48 male rats were randomly divided into 8 groups (n=6) and were treated intraperitoneally for 14 days with normal saline, resveratrol (2, 8, 20 mg/kg/day), morphine (20 mg/kg/day) and morphine (20 mg/kg/day) + resveratrol (2, 8, 20 mg/kg/day). At the end of experiments, sperm parameters (sperm cell viability, count, motility and morphology), testis weight, the diameter of seminiferous tubules, testosterone hormone level and nitric oxide were analyzed. The data were analyzed by SPSS software for windows (version 20) using one-way ANOVA test followed by Tukey’s post hoc test, and P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|