Obesity-associated Blunted Subcutaneous Adipose Tissue Blood Flow After Meal Improves After Bariatric Surgery

Autor:	Teemu Saari, Jukka Koffert, Henri Honka, Saila Kauhanen, Mueez U-Din, Nils Wierup, Andreas Lindqvist, Leif Groop, Kirsi A Virtanen, Pirjo Nuutila
Rok vydání:	2022
Předmět:	Endocrinology Adipose Tissue Diabetes Mellitus Type 2 Endocrinology Diabetes and Metabolism Biochemistry (medical) Clinical Biochemistry Subcutaneous Fat Bariatric Surgery Humans Gastric Inhibitory Polypeptide Obesity Intra-Abdominal Fat Biochemistry
Zdroj:	The Journal of Clinical Endocrinology & Metabolism. 107:1930-1938
ISSN:	1945-7197 0021-972X
DOI:	10.1210/clinem/dgac191
Popis:	Context Glucose-dependent insulinotropic peptide (GIP) and meal ingestion increase subcutaneous adipose tissue (SAT) perfusion in healthy individuals. The effects of GIP and a meal on visceral adipose tissue (VAT) perfusion are unclear. Objective Our aim was to investigate the effects of meal and GIP on VAT and SAT perfusion in obese individuals with type 2 diabetes mellitus (T2DM) before and after bariatric surgery. Methods We recruited 10 obese individuals with T2DM scheduled for bariatric surgery and 10 control individuals. Participants were studied under 2 stimulations: meal ingestion and GIP infusion. SAT and VAT perfusion was measured using 15O-H2O positron emission tomography–magnetic resonance imaging at 3 time points: baseline, 20 minutes, and 50 minutes after the start of stimulation. Obese individuals were studied before and after bariatric surgery. Results Before bariatric surgery the responses of SAT perfusion to meal (P = .04) and GIP-infusion (P = .002) were blunted in the obese participants compared to controls. VAT perfusion response did not differ between obese and control individuals after a meal or GIP infusion. After bariatric surgery SAT perfusion response to a meal was similar to that of controls. SAT perfusion response to GIP administration remained lower in the operated-on than control participants. There was no change in VAT perfusion response after bariatric surgery. Conclusion The vasodilating effects of GIP and meal are blunted in SAT but not in VAT in obese individuals with T2DM. Bariatric surgery improves the effects of a meal on SAT perfusion, but not the effects of GIP. Postprandial increase in SAT perfusion after bariatric surgery seems to be regulated in a GIP-independent manner.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba37d9bfef4eff461f5a702d883f6cc https://doi.org/10.1210/clinem/dgac191 Zobrazit plný text záznamu