Maternal Separation Does Not Produce a Significant Behavioral Change in Mice
| Autor: | Hin San Ho, Hyunsoo Shawn Je, Anna Yoonsu Song, Joey Low, Shawn Tan |
|---|---|
| Přispěvatelé: | School of Biological Sciences |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Emotional memories Short Communication Separation (statistics) Early life stress Male mice Anxiety Bioinformatics 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Maternal separation with early weaning Genetic predisposition medicine Early-life stress Maternal separation Depression Early weaning business.industry Early-life Stress Maternal Separation Early life Science::Biological sciences [DRNTU] 030104 developmental biology Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Experimental Neurobiology |
| ISSN: | 2093-8144 1226-2560 |
| DOI: | 10.5607/en.2017.26.6.390 |
| Popis: | Early life adversities together with genetic predispositions have been associated with elevated risks of neuropsychiatric disorders during later life. In order to investigate the underlying mechanisms, many chronic, early-life stress paradigms in multiple animal models have been developed. Previously, studies reported that maternal separation (MS) in the early postnatal stages triggers depression-and/or anxiety-like behaviors in rats. However, similar studies using mice have reported inconsistent behavioral outcomes. In this study, we sought to assess behavioral outcomes from two different early-life stress paradigms; a conventional 3-hour MS and a maternal separation with early weaning (MSEW) paradigm using C57BL/6J male mice with independent cohorts. Our data demonstrated that both MS and MSEW paradigms did not produce reported behavioral anomalies. Therefore, MS paradigms in mice require further validation and modification. Graphical Abstract |
| Databáze: | OpenAIRE |
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