Serum inhibin B may be a reliable marker of the presence of testicular spermatozoa in patients with nonobstructive azoospermia
| Autor: | Anibal A. Acosta, J.C. Calamera, Sabrina De Vincentiis, Santiago Brugo-Olmedo, Florencia Nodar, F. Urrutia |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
endocrine system endocrine system diseases medicine.drug_class Biopsy Obstructive azoospermia Semen analysis urologic and male genital diseases Statistics Nonparametric Semen collection Andrology Follicle-stimulating hormone Predictive Value of Tests Pregnancy Testis medicine Humans Inhibins Prospective Studies reproductive and urinary physiology Cryopreservation Azoospermia medicine.diagnostic_test urogenital system business.industry Obstetrics and Gynecology Oligospermia medicine.disease Spermatozoa Testicular sperm extraction ROC Curve Reproductive Medicine Karyotyping Female Follicle Stimulating Hormone Gonadotropin business Percutaneous epididymal sperm aspiration Biomarkers Semen Preservation |
| Zdroj: | Fertility and Sterility. 76:1124-1129 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/s0015-0282(01)02866-7 |
| Popis: | Objective: To establish the predictive value of serum inhibin B levels as an indicator of the presence of testicular spermatozoa in nonobstructive azoospermia, compared with the traditional serum FSH marker. Design: Prospective study. Setting: Private high-complexity reproductive center with university affiliation. Patient(s): Seventy-eight patients with nonobstructive azoospermia, 15 patients with obstructive azoospermia, and 10 fertile volunteers. Intervention(s): Blood samples, testicular sperm extraction, percutaneous epididymal sperm aspiration, and semen collection. Main Outcome Measure(s): Serum levels of inhibin B and FSH and presence of spermatozoa on TESE, PESA, or regular semen analysis. Result(s): Patients with nonobstructive azoospermia has significantly higher levels of serum FSH and significantly lower levels of inhibin B. Mean inhibin B serum levels were significantly higher in patients with nonobstructive azoospermia who had spermatozoa on TESE than in those in whom no spermatozoa were found (89.31 ± 73.24 pg/mL vs. 19.23 ± 22.34 pg/mL), but mean FSH serum levels did not have similar predictive power (21.37 ± 12.92 IU/mL vs. 19.27 ± 10.28 IU/mL). The cut-off level of inhibin B separating both groups, as determined by the receiver-operating characteristic curves, was >53 pg/mL. Conclusion(s): Serum inhibin B level seems to be more accurate than serum FSH level in prediction of the presence of testicular spermatozoa in patients with nonobstructive azoospermia. |
| Databáze: | OpenAIRE |
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