Overexpression of Cyclooxygenase-2 in Noncancerous Liver Tissue Increases the Postoperative Recurrence of Hepatocellular Carcinoma in Patients with Hepatitis B Virus-Related Cirrhosis
| Autor: | Wei-Dong Jia, Yan Chang, Juan Jin, Xiaoqiu Wang, Bing Hu, Chu-Shu Ji, Wei Wei, Jian Chen, Ke Chen, Yi-Fu He |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Carcinoma Hepatocellular Cirrhosis medicine.medical_treatment medicine.disease_cause Gastroenterology Liver Function Tests Predictive Value of Tests Risk Factors Internal medicine Biomarkers Tumor medicine Carcinoma Hepatectomy Humans lcsh:RC799-869 Aged Proportional Hazards Models Hepatitis B virus Chi-Square Distribution medicine.diagnostic_test business.industry Liver Neoplasms General Medicine Middle Aged Hepatitis B Prognosis medicine.disease Immunohistochemistry digestive system diseases Survival Rate Cyclooxygenase 2 Hepatocellular carcinoma Female Original Article lcsh:Diseases of the digestive system. Gastroenterology Neoplasm Recurrence Local Liver cancer business Liver function tests |
| Zdroj: | Canadian Journal of Gastroenterology, Vol 24, Iss 7, Pp 435-440 (2010) |
| ISSN: | 0835-7900 |
| DOI: | 10.1155/2010/872570 |
| Popis: | BACKGROUND: Many previous studies have evaluated the histopathological features of tumours as risk factors for postoperative recurrence in hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC). However, there have been few large studies investigating the relationship between cyclooxygenase-2 (COX-2) expression in non-cancerous regions of the liver and postoperative recurrence in the remnant liver, especially in HBV-related HCC.OBJECTIVE: To evaluate the significance of COX-2 expression levels in noncancerous liver regions as a prognostic indicator of HCC in patients with HBV-related cirrhosis.METHODS: A total of 124 patients who underwent curative resection for HCC were reviewed retrospectively. Immunohistochemistry was used to evaluate the expression of COX-2 in noncancerous liver tissue. Clinicopathological variables were compared between patients with high COX-2 expression (n=58 [COX-2-positive group]) and patients with low COX-2 expression (n=66; [COX-2-negative group]). Univariate and multivariate analyses were performed to identify factors that affected disease recurrence.RESULTS: There was a significant correlation between COX-2 expression and alanine aminotransferase levels and vascular invasion. The recurrence-free survival rates in the COX-2-positive group were significantly lower than the rates in the COX-2-negative group. On multivariate analysis, the overexpression of COX-2 in noncancerous liver regions was found to be an unfavourable prognostic indicator for the recurrence of HCC.CONCLUSIONS: The results of the current study suggest that over-expression of COX-2 in noncancerous liver regions is an independent and significant indicator predictive of early recurrence of HCC in patients with HBV-related cirrhosis. |
| Databáze: | OpenAIRE |
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