Modulating the interhemispheric activity balance in the intraparietal sulcus using real-time fMRI neurofeedback: Development and proof-of-concept
| Autor: | Dante Mantini, Tianlu Wang, Céline R. Gillebert, Ronald Peeters |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Brain activity and meditation
medicine.medical_treatment dPSC differential percent signal change EPI: echoplanar image ComputingMilieux_LEGALASPECTSOFCOMPUTING lcsh:RC346-429 QCM Questionnaire for current Motivation 0302 clinical medicine FWHM full-width at half maximum Parietal Lobe GLM general linear model PANAS Positive and Negative Affect Scale TR repetition time TVA: Theory of Visual Attention TE echo time Brain Mapping Rehabilitation medicine.diagnostic_test 05 social sciences ROI region-of-interest Neurofeedback Magnetic Resonance Imaging Visual field Intraparietal sulcus Neurology fMRI functional magnetic resonance imaging lcsh:R858-859.7 medicine.symptom Psychology medicine.medical_specialty MNI Montreal Neurological Institute Cognitive Neuroscience lcsh:Computer applications to medicine. Medical informatics 050105 experimental psychology Perceptual Disorders 03 medical and health sciences Physical medicine and rehabilitation Hemispatial neglect medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging lcsh:Neurology. Diseases of the nervous system Visual attention Balance (ability) SE standard error NF neurofeedback BOLD blood oxygen level-dependent IPS intraparietal sulcus prognosis outcomes" edited by Claire Wilcox and Vince Calhoun Real-time fMRI Neurology (clinical) Visual Fields Functional magnetic resonance imaging MRI magnetic resonance imaging 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage : Clinical NeuroImage: Clinical, Vol 28, Iss, Pp 102513-(2020) |
| ISSN: | 2213-1582 |
| DOI: | 10.1016/j.nicl.2020.102513 |
| Popis: | Highlights • We usied a rtfMRI neurofeedback to modulate interhemispheric IPS activity balance. • Six healthy individuals healthy hea were recruited for a proof-of-concept study. • Two of the six successfully learnt to modulate this balance using rtfMRI neurofeedback. • Neurofeedback did not change the behavioural distribution of attention in the learners. • The results have implications for the rehabilitation of post-stroke hemineglect. The intraparietal sulcus (IPS) plays a key role in the distribution of attention across the visual field. In stroke patients, an imbalance between left and right IPS activity has been related to a spatial bias in visual attention characteristic of hemispatial neglect. In this study, we describe the development and implementation of a real-time functional magnetic resonance imaging neurofeedback protocol to noninvasively and volitionally control the interhemispheric IPS activity balance in neurologically healthy participants. Six participants performed three neurofeedback training sessions across three weeks. Half of them trained to voluntarily increase brain activity in left relative to right IPS, while the other half trained to regulate the IPS activity balance in the opposite direction. Before and after the training, we estimated the distribution of attention across the visual field using a whole and partial report task. Over the course of the training, two of the three participants in the left-IPS group increased the activity in the left relative to the right IPS, while the participants in the right-IPS group were not able to regulate the interhemispheric IPS activity balance. We found no evidence for a decrease in resting-state functional connectivity between left and right IPS, and the spatial distribution of attention did not change over the course of the experiment. This study indicates the possibility to voluntarily modulate the interhemispheric IPS activity balance. Further research is warranted to examine the effectiveness of this technique in the rehabilitation of post-stroke hemispatial neglect. |
| Databáze: | OpenAIRE |
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