β-Lactamase-Positive Strains of Haemophilus influenzae: Susceptibility to and Inactivation of β-Lactam Antibiotics
| Autor: | C R Adams, K K Tu, P A Robinson, E L Anderson |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
medicine.drug_class
Antibiotics Cefoperazone Cefotaxime Microbial Sensitivity Tests medicine.disease_cause beta-Lactamases Microbiology Haemophilus influenzae Ampicillin polycyclic compounds Medicine Cefamandole Moxalactam Mezlocillin business.industry Ceftriaxone General Medicine Anti-Bacterial Agents business medicine.drug |
| Zdroj: | Southern Medical Journal. 78:643-646 |
| ISSN: | 0038-4348 |
| DOI: | 10.1097/00007611-198506000-00006 |
| Popis: | Susceptibility and time-kill studies were done with low and high inocula of both beta-lactamase-positive and -negative strains of Haemophilus influenzae with cefamandole, ampicillin, cefoperazone, mezlocillin, moxalactam, and ceftriaxone. Bioassay was done to test for antibiotic inactivation by beta-lactamase-positive strains. All six antibiotics were highly active against the low inoculum (10(4) to 10(5) colony-forming units/ml) of beta-lactamase-negative strains; ceftriaxone, moxalactam, and cefoperazone were equally active against the same inoculum concentration of beta-lactamase-positive strains. In contrast, cefamandole, mezlocillin, and ampicillin were less active against the low inoculum of beta-lactamase-positive H influenzae. A marked inoculum effect occurred with the high inoculum (10(7) to 10(8) CFU/ml) with all six antibiotics, regardless of beta-lactamase production. In time-kill studies, marked differences in bacterial killing resulted after low and high inocula. Ampicillin, cefamandole, cefoperazone, and mezlocillin were rapidly inactivated by the high inoculum of beta-lactamase-positive H influenzae. |
| Databáze: | OpenAIRE |
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