Clinical comparison of the effects of isoflurane or propofol anaesthesia on mean arterial blood pressure and ventilation in dogs undergoing orthopaedic surgery receiving epidural anaesthesia
| Autor: | I.A. Gómez de Segura, Delia Aguado, R. Cediel, Rocío Bustamante, Susana Canfrán |
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| Rok vydání: | 2018 |
| Předmět: |
Anesthesia
Epidural Male Mean arterial pressure 040301 veterinary sciences medicine.medical_treatment 0403 veterinary science 03 medical and health sciences Dogs 0302 clinical medicine 030202 anesthesiology medicine Animals Arterial Pressure Orthopedic Procedures Prospective Studies Dexmedetomidine Propofol Mechanical ventilation Bupivacaine Isoflurane General Veterinary business.industry Respiration 04 agricultural and veterinary sciences Respiration Artificial Epidural space medicine.anatomical_structure Anesthesia Breathing Female Animal Science and Zoology business medicine.drug |
| Zdroj: | The Veterinary Journal. 233:49-54 |
| ISSN: | 1090-0233 |
| DOI: | 10.1016/j.tvjl.2018.01.002 |
| Popis: | The aim of this study was to compare the effects on mean arterial pressure (MAP) and ventilation of propofol total IV anaesthesia (TIVA) and isoflurane as anaesthetic maintenance in healthy dogs undergoing orthopaedic surgery, with epidural anaesthesia. Dogs were premedicated IM with dexmedetomidine (4μg/kg) and methadone (0.3mg/kg), induced with IV propofol (0.65-5mg/kg) and randomly assigned to be maintained with isoflurane (group I) or propofol (group P). Isoflurane end-tidal concentration (EtISO) and propofol infusion rate were adjusted during the surgery to maintain a suitable anaesthetic depth. All dogs received bupivacaine (1mg/kg) and morphine (0.1mg/kg) in the lumbosacral epidural space (total volume 0.2mL/kg). MAP was recorded every 5min during the procedure. Statistical analysis was performed using parametric (Student's t test) and nonparametric (Mann-Whitney U-test, chi-square) tests, as appropriate. Anaesthetic maintenance in groups I and P was accomplished by providing a mean EtISO of 1.12±0.15% and a mean propofol infusion rate of 15.0±4.7mg/kg/h, respectively. MAP was significantly higher in group P than in group I (92±17mmHg versus 78±10mmHg; P=0.021). Eleven dogs in group P and two dogs in group I reached an EtCO2>7.3kPa, requiring mechanical ventilation (P=0.001). In combination with epidural anaesthesia, propofol TIVA improved MAP and is a suitable alternative to isoflurane in orthopaedic surgery of the hind limb in healthy dogs. Nevertheless, since it was associated with increased respiratory depression, mechanical ventilation should be available. |
| Databáze: | OpenAIRE |
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