Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease
| Autor: | Lee, JC, Biasci, D, Roberts, R, Gearry, RB, Mansfield, JC, Ahmad, T, Prescott, NJ, Satsangi, J, Wilson, DC, Jostins, L, Anderson, CA, UK IBD Genetics Consortium, Traherne, JA, Lyons, PA, Parkes, M, Smith, KGC |
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| Přispěvatelé: | Lee, James [0000-0001-5711-9385], Biasci, Daniele [0000-0003-3148-8152], Traherne, James [0000-0002-6003-8559], Lyons, Paul [0000-0001-7035-8997], Parkes, Miles [0000-0002-6467-0631], Smith, Kenneth [0000-0003-3829-4326], Apollo - University of Cambridge Repository |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Genotype Genome-wide association study Disease Biology Bioinformatics Inflammatory bowel disease Polymorphism Single Nucleotide Article outcomes research 03 medical and health sciences 0302 clinical medicine Crohn Disease Polymorphism (computer science) inflammatory bowel disease Genetic variation Genetics medicine Journal Article Humans Genetic Predisposition to Disease Crohn's disease Genome medicine.disease Prognosis 3. Good health 030104 developmental biology genome-wide association studies 030211 gastroenterology & hepatology Female Colitis Ulcerative Disease Susceptibility Outcomes research Genome-Wide Association Study |
| Zdroj: | Nature Genetics Lee, J C, Biasci, D, Roberts, R, Gearry, R B, Mansfield, J C, Ahmad, T, Prescott, N J, Satsangi, J, Wilson, D C, Jostins, L, Anderson, C A, Traherne, J A, Lyons, P A & Parkes, M & Smith, K G C 2017, ' Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease ', Nature Genetics, vol. 49, no. 2, pp. 262-268 . https://doi.org/10.1038/ng.3755 Lee, J C, Biasci, D, Roberts, R, Gearry, R B, Mansfield, J C, Ahmad, T, Prescott, N J, Satsangi, J, Wilson, D C, Jostins, L, Anderson, C A, Traherne, J A, Lyons, P A, Parkes, M & Smith, K G C 2017, ' Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease ', Nature Genetics, vol. 49, no. 2, pp. 262-268 . https://doi.org/10.1038/ng.3755 |
| ISSN: | 1061-4036 |
| DOI: | 10.1038/ng.3755 |
| Popis: | For most immune-mediated diseases, the main determinant of patient well-being is not the diagnosis itself but instead the course that the disease takes over time (prognosis)1,2,3. Prognosis may vary substantially between patients for reasons that are poorly understood. Familial studies support a genetic contribution to prognosis4,5,6, but little evidence has been found for a proposed association between prognosis and the burden of susceptibility variants7,8,9,10,11,12,13. To better characterize how genetic variation influences disease prognosis, we performed a within-cases genome-wide association study in two cohorts of patients with Crohn's disease. We identified four genome-wide significant loci, none of which showed any association with disease susceptibility. Conversely, the aggregated effect of all 170 disease susceptibility loci was not associated with disease prognosis. Together, these data suggest that the genetic contribution to prognosis in Crohn's disease is largely independent of the contribution to disease susceptibility and point to a biology of prognosis that could provide new therapeutic opportunities. |
| Databáze: | OpenAIRE |
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