Physiologically Assessed Coronary Collateral Flow and Intracoronary Growth Factor Concentrations in Patients With 1- to 3-Vessel Coronary Artery Disease
| Autor: | Bernhard Meier, Ali Garachemani, Franz R. Eberli, Martin Fleisch, Christian Seiler, Michael Billinger |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A medicine.medical_specialty Arteriosclerosis Basic fibroblast growth factor Collateral Circulation Neovascularization Physiologic Coronary Disease Endothelial Growth Factors Coronary Angiography Coronary artery disease Coronary circulation chemistry.chemical_compound Coronary Circulation Physiology (medical) Internal medicine medicine Humans Lymphokines Vascular Endothelial Growth Factors business.industry Venous Plasma Heparin Collateral circulation medicine.disease Vascular endothelial growth factor Vascular endothelial growth factor A medicine.anatomical_structure chemistry Cardiology Female Fibroblast Growth Factor 2 Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Circulation. 100:1945-1950 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/01.cir.100.19.1945 |
| Popis: | Background —The purpose of this study was to test the hypothesis that there is a relation between collateral flow and intracoronary concentrations of basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) and that the combined concentrations of both growth factors and the extent of coronary artery disease (CAD) play a role as covariables in such an association. Methods and Results —In 76 patients undergoing balloon angioplasty, a collateral flow index (CFI, no units) was determined with sensor-tipped guidewires. Simultaneously, serum concentrations of bFGF and VEGF, obtained at the aortic root from the ostium of the collateralized coronary artery (n=76) and from the distal position of the occluded coronary artery (n=34), were determined. There was a direct correlation between CFI and distal VEGF ( r =0.33, P =0.05) but not bFGF concentrations. Focusing on the proximal sampling site, there was a direct correlation between CFI and both bFGF ( r =0.29, P =0.01) and VEGF concentrations ( r =0.44, P r =0.51, P r =0.34, P =0.048). There was a trend toward higher proximal VEGF concentrations in patients with higher numbers of coronary stenotic lesions ( r =0.25, P =0.03). Conclusions —In patients with CAD, there is an association between a directly measured index of collateral flow and intracoronary concentrations of bFGF and VEGF. This direct relation is dependent on the site of blood sampling within the coronary artery tree. The association is closest when the combined bFGF and VEGF concentrations are taken into account. In the case of VEGF, it is influenced by the degree of coronary atherosclerosis. |
| Databáze: | OpenAIRE |
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