Figure S1-S17, Table S3 from A Functional Taxonomy of Tumor Suppression in Oncogenic KRAS–Driven Lung Cancer

Autor: Monte M. Winslow, Charles Swanton, Dmitri A. Petrov, Christopher D. McFarland, Le Cong, Christian A. Kunder, Wen-Yang Lin, Maryam Yousefi, Shi Ya C. Lee, Leo C. Chen, King L. Hung, Rui Tang, Emily L. Ashkin, Emily G. Shuldiner, Nicholas W. Hughes, Christopher W. Murray, Laura Andrejka, Min K. Tsai, Chuan Li, Su Kit Chew, Hongchen Cai
Rok vydání: 2023
Popis: (Updated, with minor text changes and rearrangements.) Figure S1-S4 (related to Figure 1) provide details on the selected genes and method. Figure S5 (related to Figure 2) shows the percentiles of all sgRNAs. Figure S6-S8 (related to Figure 3) present Stag2 validation and mechanistic investigations. Figure S9 (related to Figure 4) presents the percentiles of all genotypes at 26-week stage. Figure S10-S11 (related to Figure 5) suggest that genes that regulate tumor number are consistent across datasets. Figure S12 (related to Figure 6) provides additional evidence for the genes that regulate rare large tumors. Figure S13-S14 measure the influences of crowding and sex on Tuba-seq. Figure S15-S16 and Table S3 evaluate the specificity and sensitivity of Tuba-seq. Figure S17 (related to Figure 7) shows the complementarity of Tuba-seq to human datasets.
Databáze: OpenAIRE