Thyroid carcinoma after Chernobyl latent period, morphology and aggressiveness
| Autor: | S L Vowler, Mykola Tronko, Geraldine Thomas, Virginia A. LiVolsi, E P Demidchik, E. Lushnikov, A. F. Tsyb, T Bogdanova, A.A. Abrosimov, J Rosai, E D Williams, Yu Sidorov, Masahiro Ito |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Radioactive Fallout endocrine system Cancer Research Pathology medicine.medical_specialty Time Factors Adolescent Cellular differentiation DNA Mutational Analysis Nuclear Receptor Coactivators Mice Transgenic Biology medicine.disease_cause tumour latency Chernobyl Thyroid carcinoma Mice Fibrosis Follicular phase medicine Animals Humans Neoplasm Invasiveness Thyroid Neoplasms Latency (engineering) Child Thyroid cancer Oncogene Proteins Mutation Molecular and Cellular Pathology Infant Newborn Infant Cell Differentiation DNA Neoplasm Prognosis medicine.disease thyroid carcinoma Phenotype Carcinoma Papillary Oncology Child Preschool Female RET Radioactive Hazard Release Ukraine Power Plants Transcription Factors |
| Zdroj: | Scopus-Elsevier British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | The large numbers of papillary thyroid carcinomas that have occurred in those exposed to high levels of short-lived isotopes in fallout after Chernobyl provide a unique opportunity to correlate latency and tumour biology. We show that short latency is associated with tumours with a phenotype that is significantly less structurally differentiated, shows significantly less peritumour fibrosis, and significantly more invasive spread when compared to tumours with a longer latent period. In contrast, the type of differentiation (papillary or follicular architecture) is associated with age at exposure. These findings suggest that the initial mutation at the time of exposure played a major role in tumour latency and aggressiveness. We and others have shown that RET-PTC3 rearrangements are associated with the solid morphology seen in these short latency tumours, while classical papillary carcinomas more often show RET-PTC1 rearrangements. Studies in transgenic mice show similar findings, and in vitro studies show that RET-PTC3 induces more rapid growth than RET-PTC1. We therefore suggest that the solid morphology, high frequency of RET-PTC3 rearrangements and aggressive behaviour noted in early investigations of post-Chernobyl tumours were characteristic of short latency rather than the nature of the mutagen, and that successive overlapping waves of papillary carcinoma with differing latency, differing patterns of mutations and differing clinical behaviour are occurring in those exposed to Chernobyl fallout. |
| Databáze: | OpenAIRE |
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