Vaccination with theospA- andospB-Negative Borrelia burgdorferi Strain 50772 Provides Significant Protection against Canine Lyme Disease
| Autor: | Steven D. Lovrich, Jennifer C. Dant, Steven M. Callister, Rhonda L. LaFleur, Terri L. Wasmoen, Dean A. Jobe |
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| Rok vydání: | 2015 |
| Předmět: |
Microbiology (medical)
Lipoproteins Clinical Biochemistry Immunology Tick Vaccines Attenuated Placebo complex mixtures Placebos Dogs Lyme disease Animals Immunology and Allergy Medicine Dog Diseases Borrelia burgdorferi Vaccines Antigens Bacterial Lyme Disease Strain (chemistry) biology medicine.diagnostic_test business.industry Vaccination bacterial infections and mycoses medicine.disease biology.organism_classification Virology Bacterial vaccine Treatment Outcome Antigens Surface Bacterial Vaccines Skin biopsy business Bacterial Outer Membrane Proteins |
| Zdroj: | Clinical and Vaccine Immunology. 22:836-839 |
| ISSN: | 1556-679X 1556-6811 |
| DOI: | 10.1128/cvi.00193-15 |
| Popis: | Beagles received placebo orospA- andospB-negativeBorrelia burgdorferibefore a tick challenge. A total of 28 (41%) ticks and skin biopsy specimens from each control dog (n= 10) containedB. burgdorferi. In contrast, 12 (19%) ticks recovered from the vaccine recipients (n= 10) were infected (P= 0.0077), and 5 dogs yielded spirochetes from the skin biopsy specimens (P= 0.0325). In addition, 9 (90%) placebo recipients and 4 (40%) vaccine recipients developed joint abnormalities (P= 0.0573). Therefore, vaccination with theospA- andospB-negative spirochete provided significant protection against Lyme disease. |
| Databáze: | OpenAIRE |
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