Effect of Telmisartan on the Regression of the Left Ventricular Hypertrophy in the Patients of Essential Hypertension
| Autor: | Ramani Yr, Das Mc, Misra Kh |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
hypertension Clinical Biochemistry Volume overload lcsh:Medicine telmisartan Left ventricular hypertrophy Essential hypertension Muscle hypertrophy Internal medicine medicine cardiovascular diseases Angiotensin II receptor type 1 business.industry lcsh:R General Medicine medicine.disease Atenolol left ventricular hypertrophy Endocrinology Blood pressure Cardiology Original Article Telmisartan business medicine.drug |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 7, Iss 7, Pp 1352-1355 (2013) |
| ISSN: | 2249-782X |
| DOI: | 10.7860/jcdr/2013/5416.3127 |
| Popis: | Introduction: An increase in the Left Ventricular Mass as a result of muscle hypertrophy, has emerged as a powerful pressure independent risk factor for the cardiovascular mortality and morbidity. It is associated with a risk of death that is 3 times greater than the risk which is associated with hypertension alone. For the development of Left Ventricular Hypertrophy (LVH), in addition to a chronic increase in the pressure and/or volume overload, an elevation in the plasma ACE activity, plasma aldosterone levels, and the angiotensin-II concentrations play a major role .In this study, the effect of Telmisartan, a selective angiotension-II receptor blocker, was compared with that of Atenolol, a selective β1 adrenergic receptor blocker, on the regression of LVH in the patients of essential hypertension. Material and Method: Essential hypertensive patients with LVH were selected for this study, as per the inclusion and exclusion criteria. This study was carried out on two groups of hypertensive patients with LVH: Group-1 : The patients who were taking telmisartan 80 mg OD. Group-2 : The patients who were taking atenolol 50 mg OD. The blood pressure was measured and echocardiography was done in both the groups, prior to the treatment and 6 months after the treatment in the Department of Cardiology, MKCG Medical College Hospital, Brahmapur, India. The data were analysed by using the Student’s ‘t’ test. Results: In the cases of Left Ventricular Mass Index (LVMI), which is a better indicator of LVH, in the Atenolol group, the mean value changed from 143.93 ± 2.44 gm/m2 to 130.16 ± 2.88 gm/m2 (t=5.83,p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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