Deleterious Ca-independent NOS activity after oxidative stress in rat striatum
| Autor: | Roger G. Boulu, Laurent Lecanu, Michel Plotkine, Hicham Boughali, Isabelle Margaill, Bertrand Cohen-Tenoudji |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Free Radicals Central nervous system Striatum medicine.disease_cause Guanidines Cyclic N-Oxides Rats Sprague-Dawley Lesion Necrosis Internal medicine Basal ganglia medicine Animals Enzyme Inhibitors biology Chemistry General Neuroscience Free Radical Scavengers Free radical scavenger Corpus Striatum Malonates Rats Nitric oxide synthase Oxidative Stress Endocrinology medicine.anatomical_structure Enzyme inhibitor biology.protein Calcium Nitrogen Oxides Nitric Oxide Synthase medicine.symptom Oxidative stress |
| Zdroj: | NeuroReport. 9:559-563 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/00001756-199802160-00032 |
| Popis: | The aim of this study was to assess whether oxidative stress induces deleterious NOS activity in the central nervous system (CNS). For this purpose, the mitochondrial toxin malonate, which promotes free radical production, was infused into the left striatum of rats. Forty-eight hours after injection, an increase in Ca-independent NOS activity was observed in the injected striatum. This increase was blocked by alpha-phenyl-tert-butyl-nitrone, a free radical scavenger, and by aminoguanidine, an inhibitor of NOS 2. Both these drugs reduced the malonate-induced striatal necrotic volume. These results suggest that in the CNS oxidative stress can induce a Ca-independent NOS, probably of type 2, which contributes to the lesion. |
| Databáze: | OpenAIRE |
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