Development of a bioactive glass-polymer composite for wound healing applications
| Autor: | João F. Mano, Aldo R. Boccaccini, Marina Trevelin Souza, D. Moura, G. Rella, Liliana Liverani, Gisela M. Luz |
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| Rok vydání: | 2017 |
| Předmět: |
Materials science
Polymers Polyesters Metal ions in aqueous solution Nanoparticle chemistry.chemical_element Biocompatible Materials Bioengineering 02 engineering and technology 010402 general chemistry 01 natural sciences law.invention Biomaterials chemistry.chemical_compound law Acetone Composite material Wound Healing Tissue Engineering Doping technology industry and agriculture 021001 nanoscience & nanotechnology Electrospinning 0104 chemical sciences Solvent chemistry Chemical engineering Mechanics of Materials Bioactive glass Glass 0210 nano-technology Cobalt |
| Zdroj: | Materials Science and Engineering: C. 76:224-232 |
| ISSN: | 0928-4931 |
| Popis: | This study reports the production and characterization of a composite material for wound healing applications. A bioactive glass obtained by sol-gel process and doped with two different metal ions was investigated. Silver (Ag) and cobalt (Co) were chosen due to their antibacterial and angiogenic properties, respectively, very beneficial in the wound healing process. Poly(e-caprolactone) (PCL) fibers were produced by electrospinning (ES) from a polymeric solution using acetone as a solvent. After optimization of the ES parameters, two main suspensions were prepared, namely: PCL containing bioactive glass nanoparticles (BG-NP) and PCL with Ag2O and CoO doped BG-NP (DP BG-NP), which were processed with different concentrations of BG-NP (0.25%, 0.5% and 0.75wt%). The composite membranes were characterized in terms of morphology, fiber diameter, weight loss, mineralization potential and mechanical performance. |
| Databáze: | OpenAIRE |
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