Monkeypox Rash Severity and Animal Exposures in the Democratic Republic of the Congo
| Autor: | Neville K. Kisalu, Emile W. Okitolonda, Anne W. Rimoin, Brian Cowell, Vivian H. Alfonso, Hayley R. Ashbaugh, Nicole A. Hoff, Prime Mulembakani, Cyrus Sinai, Douglas S. Morier, Alvan Cheng, Jean-Jacques Muyembe-Tamfum, Reena H. Doshi, Adva Gadoth |
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| Rok vydání: | 2018 |
| Předmět: |
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medicine.medical_specialty 040301 veterinary sciences Health Toxicology and Mutagenesis 030231 tropical medicine macromolecular substances ANIMAL EXPOSURE Polymerase Chain Reaction Viral Zoonoses 0403 veterinary science 03 medical and health sciences Monkeypox 0302 clinical medicine medicine Animals Humans Monkeypox virus Ecology biology business.industry 04 agricultural and veterinary sciences Exanthema medicine.disease biology.organism_classification Rash Dermatology Additional research Cross-Sectional Studies Animal ecology Democratic Republic of the Congo Female medicine.symptom business |
| Zdroj: | EcoHealth. 17(1) |
| ISSN: | 1612-9210 |
| Popis: | Experimental studies have suggested a larger inoculum of monkeypox virus may be associated with increased rash severity; however, little data are available on the relationship between specific animal exposures and rash severity in endemic regions. Using cross-sectional data from an active surveillance program conducted between 2005 and 2007 in the Sankuru Province of the Democratic Republic of the Congo, we explored the possible relationship between rash severity and exposures to rodents and non-human primates among confirmed MPX cases. Among the 223 PCR-confirmed MPX cases identified during active surveillance, the majority of cases (n = 149) presented with mild rash (5–100 lesions) and 33% had a more serious presentation (> 100 lesions). No association between exposure to rodents and rash severity was found in the multivariable analysis. Those that self-reported hunting NHP 3 weeks prior to onset of MPX symptoms had 2.78 times the odds of severe rash than those that did not report such exposure (95% CI: 1.18, 6.58). This study provides a preliminary step in understanding the association between animal exposure and rash severity and demonstrates correlation with exposure to NHPs and human MPX presentation. Additional research exploring the relationship between rash severity and NHPs is warranted. |
| Databáze: | OpenAIRE |
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