miR-409-3p suppresses breast cancer cell growth and invasion by targeting Akt1
| Autor: | Guoqiang Zhang, Qifeng Yang, Zengyan Liu, H. Xu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Untranslated region Biophysics Breast Neoplasms Context (language use) Biology medicine.disease_cause Biochemistry Mice 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Cell Movement Cell Line Tumor microRNA medicine Animals Humans Genes Tumor Suppressor Neoplasm Invasiveness Molecular Biology Cells Cultured Cell Proliferation Cell growth Gene targeting Cancer Cell Biology medicine.disease Molecular biology MicroRNAs 030104 developmental biology 030220 oncology & carcinogenesis Gene Targeting embryonic structures Cancer research Carcinogenesis Proto-Oncogene Proteins c-akt |
| Zdroj: | Biochemical and Biophysical Research Communications. 469:189-195 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2015.11.099 |
| Popis: | Altered levels and functions of microRNAs (miRNAs) are correlated with carcinogenesis. While miR-409-3p has been shown to play important roles in several cancer types, its function in the context of breast cancer (BC) remains unknown. In this study, miR-409-3p was significantly downregulated in BC tissues and cell lines, compared with the corresponding control counterparts. Overexpression of miR-409-3p inhibited BC cell proliferation, migration and invasion in vitro and suppressed tumor growth in vivo. Notably, miR-409-3p induced downregulation of Akt1 protein through binding to its 3' untranslated region (UTR). Conversely, restoring Akt1 expression rescued the suppressive effects of miR-409-3p. Our data collectively indicate that miR-409-3p functions as a tumor suppressor in BC through downregulating Akt1, supporting the targeting of the novel miR-409-3p/Akt1 axis as a potentially effective therapeutic approach for BC. |
| Databáze: | OpenAIRE |
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