Biochemical basis for increased susceptibility to Cidofovir of herpes simplex viruses with altered or deficient thymidine kinase activity
| Autor: | D B Barkhimer, M S Chen, D B Mendel |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Thymidine kinase activity
Simplexvirus food.ingredient animal diseases viruses Organophosphonates Acyclovir Viral Plaque Assay Biology medicine.disease_cause Antiviral Agents Thymidine Kinase Herpesviridae Virus Cell Line Cytosine chemistry.chemical_compound Organophosphorus Compounds food medicine Humans heterocyclic compounds Pharmacology (medical) Pharmacology virus diseases Drug Resistance Microbial Nucleosides Fibroblasts Virology Infectious Diseases Herpes simplex virus chemistry Cell culture Thymidine kinase Cidofovir Research Article |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 39:2120-2122 |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | It has been observed that herpes simplex virus mutants with deficient or altered thymidine kinase activity are more susceptible to Cidofovir (CDV; 1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine dihydrate) in tissue culture than are the parental strains. During infection of cells, the elevation of the dCTP pool by thymidine kinase mutant viruses is less than that induced by the wild-type virus. The competition between CDV diphosphate and dCTP at the viral polymerase is therefore changed in favor of CDV diphosphate, enhancing its activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|