Injury of the anterior cruciate ligament: The role of collagenase in ligament degeneration
| Autor: | Wayne H. Akeson, Kenneth K. Ishizue, F. L. Harwood, Linda Kitabayashi, David Amiel |
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| Rok vydání: | 1989 |
| Předmět: |
Male
medicine.medical_specialty Anterior cruciate ligament Knee Injuries Degeneration (medical) Menisci Tibial medicine Animals Orthopedics and Sports Medicine Collagenase activity business.industry musculoskeletal neural and ocular physiology musculoskeletal system medicine.disease ACL injury Pathophysiology Surgery Acl rupture Microbial Collagenase surgical procedures operative medicine.anatomical_structure Ligaments Articular Collagenase Ligament Collagen Rabbits business human activities medicine.drug |
| Zdroj: | Journal of Orthopaedic Research. 7:486-493 |
| ISSN: | 1554-527X 0736-0266 |
| DOI: | 10.1002/jor.1100070405 |
| Popis: | Rapid degeneration of the anterior cruciate ligament (ACL) has been observed following acute ACL rupture. An understanding of this process might explain some of the poor clinical results of primary ACL repair. We created a surgical rabbit model of acute ACL injury and developed an in vitro assay for collagenase activity in the ACL and menisci. Microscopic evaluation revealed a rapidly degenerative process in injured ACLs, with loss of cellularity and matrix organization. This was associated with a significant increase in collagenase activity and a decrease in total collagen of the injured ACLs as compared with sham-operated controls. These findings confirm the observation that cut ACL ligament ends rapidly degenerate. This degenerative process might be partly due to a response of cells intrinsic to the ACL to injury. Left unchecked, this process may be detrimental to surgical attempts for primary ACL repair. |
| Databáze: | OpenAIRE |
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