[Immunophenotypic characteristic of dendritic cells in bronchial asthma in conditions of extract opisthorchis felineus in vitro]
| Autor: | Ludmila M. Ogorodova, Tatyana Perevozchikova, Faĭt Ea, N. A. Kirillova, Elena Kremer, Khvorilova Kv |
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| Rok vydání: | 2013 |
| Předmět: |
Severe asthma
chemical and pharmacologic phenomena Stimulation Severity of Illness Index Immune system Antigen medicine Animals Humans Opisthorchis felineus Asthma CD86 Antigen Presentation biology Opisthorchis Models Immunological hemic and immune systems General Medicine Dendritic Cells biology.organism_classification medicine.disease In vitro Antigens Helminth Immunology Antigens Surface B7-2 Antigen |
| Zdroj: | Vestnik Rossiiskoi akademii meditsinskikh nauk. (5) |
| ISSN: | 0869-6047 |
| Popis: | This work shows comparative characteristics of immunogenic properties of the extract of Opisthorchis felineus in different severity of asthma using antigen presenting dendritic cells in vitro. New data on the effect of Opisthorchis felineus on the expression of surface markers of dendritic cells (CD209, HLA-DR, CD83, CD86) were received. Pronounced expression of CD209, CD86 and HLA-DR on the surface of dendritic cells in mild and severe asthma compared with healthy individuals was shown. In the stimulation of dendritic cells with extract Opisthorchis felineus in vitro weakening of CD86 expression in mild and in severe asthma was found. CD86 molecule may be a regulatory factor in the co-stimulation of dendritic cells which allows us to consider it as a potential pharmacological target for the treatment of allergic diseases. |
| Databáze: | OpenAIRE |
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