Bedside Xenon-CT Shows Lower CBF in SAH Patients with Impaired CBF Pressure Autoregulation as Defined by Pressure Reactivity Index (PRx)
| Autor: | Per Enblad, Tim Howells, Anders Lewén, Pelle Nilsson, Elham Rostami, Elisabeth Ronne-Engström, Henrik Engquist, Ulf Johnson |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Subarachnoid hemorrhage Xenon Intracranial Pressure Traumatic brain injury 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine Brain Ischemia Brain ischemia 03 medical and health sciences 0302 clinical medicine medicine Homeostasis Humans Autoregulation Arterial Pressure Cerebral perfusion pressure Intracranial pressure Aged Aged 80 and over business.industry Middle Aged Subarachnoid Hemorrhage medicine.disease Prognosis Blood pressure Cerebral blood flow Anesthesia Cerebrovascular Circulation Female Neurology (clinical) business Tomography X-Ray Computed 030217 neurology & neurosurgery |
| Zdroj: | Neurocritical care. 25(1) |
| ISSN: | 1556-0961 |
| Popis: | Subarachnoid hemorrhage (SAH) is a disease with a high rate of unfavorable outcome, often related to delayed cerebral ischemia (DCI), i.e., ischemic injury that develops days–weeks after onset, with a multifactorial etiology. Disturbances in cerebral pressure autoregulation, the ability to maintain a steady cerebral blood flow (CBF), despite fluctuations in systemic blood pressure, have been suggested to play a role in the development of DCI. Pressure reactivity index (PRx) is a well-established measure of cerebral pressure autoregulation that has been used to study traumatic brain injury, but not extensively in SAH. To study the relation between PRx and CBF in SAH patients, and to examine if PRx can be used to predict DCI. Retrospective analysis of prospectively collected data. PRx was calculated as the correlation coefficient between mean arterial blood pressure (MABP) and intracranial pressure (ICP) in a 5 min moving window. CBF was measured using bedside Xenon-CT (Xe-CT). DCI was diagnosed clinically. 47 poor-grade mechanically ventilated patients were studied. Patients with disturbed pressure autoregulation (high PRx values) had lower CBF, as measured by bedside Xe-CT; both in the early (day 0–3) and late (day 4–14) acute phase of the disease. PRx did not differ significantly between patients who developed DCI or not. In mechanically ventilated and sedated SAH patients, high PRx (more disturbed CBF pressure autoregulation) is associated with low CBF, both day 0–3 and day 4–14 after onset. The role of PRx as a monitoring tool in SAH patients needs further studying. |
| Databáze: | OpenAIRE |
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