Mouse Neuroinvasive Phenotype of West Nile Virus Strains Varies Depending upon Virus Genotype

Autor:	Miguel T. Suderman, David W.C. Beasley, Alan D.T. Barrett, Li Li
Rok vydání:	2002
Předmět:	Genotype West Nile virus viruses Molecular Sequence Data Virulence Biology Viral Nonstructural Proteins medicine.disease_cause Virus Mice Virus strain Phylogenetics Cricetinae Virology medicine Animals Phylogeny Genetics Age Factors Phenotype Disease Models Animal Female West Nile Fever
Zdroj:	Virology. 296(1):17-23
ISSN:	0042-6822
DOI:	10.1006/viro.2002.1372
Popis:	Despite recent advances in the genetics of West Nile (WN) virus, relatively little is known about the molecular basis of virulence of this virus. In particular, although the genotype of the WN virus strain that was recently introduced into North America has been determined, there have been few experimental studies on the virulence phenotype of the virus. We compared genetic and neurovirulence properties of 19 strains of WN virus, including 2 from North America, and observed significant differences in their neuroinvasive phenotype in mice and hamsters that correlated with virus genotype. Virus isolated in North America was found to be highly neuroinvasive with a lack of age-related resistance to infection in mice normally associated with mosquito-borne flaviviruses.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb861eca0c4677ae89de5bf3cb32109a Zobrazit plný text záznamu Full Text from ScienceDirect