Antitumor agents from Streptomyces anandii: gilvocarcins V, M and E
| Autor: | D. M. Balitz, J. Clardy, J. Bush, F. A. O'herron, D. E. Nettleton, Eddy Arnold, R. E. Grulich, W. T. Bradner, D. M. Vyas, T. W. Doyle |
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| Rok vydání: | 1981 |
| Předmět: |
Pharmacology
Antitumor activity Antibiotics Antineoplastic Bacteria Chemical Phenomena Stereochemistry Chemistry Antimicrobial Streptomyces anandii Combinatorial chemistry High-performance liquid chromatography Streptomyces Anti-Bacterial Agents Mice Gilvocarcin V Aminoglycosides Coumarins Drug Discovery Animals Glycosides Solvent extraction |
| Zdroj: | The Journal of Antibiotics. 34:1544-1555 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.34.1544 |
| Popis: | The isolation and structure elucidation of gilvocarcins V, M and E from Streptomyces anandii is reported. Solvent extraction and high performance liquid chromatography were employed along with NMR and X-ray crystallographic analysis. Gilvocarcins V and M showed antimicrobial activity while only gilvocarcin V demonstrated potential as an antitumor agent. |
| Databáze: | OpenAIRE |
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