In Vitro Activity of Rifampin, Rifabutin, and Rifapentine against Enterococci and Streptococci from Periprosthetic Joint Infection
| Autor: | Melissa J. Karau, Mariana Albano, Matthew P. Abdel, Daniel J. Berry, Kerryl E. Greenwood-Quaintance, Douglas R. Osmon, Caitlin P Oravec, Robin Patel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Rifabutin rifamycin Physiology medicine.drug_class 030106 microbiology Antibiotics Periprosthetic Observation medicine.disease_cause Microbiology biofilm 03 medical and health sciences 0302 clinical medicine enterococci Streptococcus mitis Genetics medicine polycyclic compounds 030212 general & internal medicine periprosthetic joint infection General Immunology and Microbiology Ecology biology Streptococcus business.industry Rifamycin Cell Biology biochemical phenomena metabolism and nutrition biology.organism_classification Rifapentine rifabutin QR1-502 rifapentine Infectious Diseases Enterococcus streptococci business rifampin medicine.drug |
| Zdroj: | Microbiology Spectrum, Vol 9, Iss 1 (2021) Microbiology Spectrum |
| ISSN: | 2165-0497 |
| Popis: | After staphylococci, streptococci and enterococci are the most frequent causes of periprosthetic joint infection (PJI). MICs and minimum biofilm bactericidal concentrations of rifampin, rifabutin, and rifapentine were determined for 67 enterococcal and 59 streptococcal PJI isolates. Eighty-eight isolates had rifampin MICs of ≤1 μg/ml, among which rifabutin and rifapentine MICs were ≤ 8 and ≤4 μg/ml, respectively. There was low rifamycin in vitro antibiofilm activity except for a subset of Streptococcus mitis group isolates. IMPORTANCE Rifampin is an antibiotic with antistaphylococcal biofilm activity used in the management of staphylococcal periprosthetic joint infection with irrigation and debridement with component retention; some patients are unable to receive rifampin due to drug interactions or intolerance. We recently showed rifabutin and rifapentine to have in vitro activity against planktonic and biofilm states of rifampin-susceptible periprosthetic joint infection-associated staphylococci. After staphylococci, streptococci and enterococci combined are the most common causes of periprosthetic joint infection. Here, we investigated the in vitro antibiofilm activity of rifampin, rifabutin, and rifapentine against 126 Streptococcus and Enterococcus periprosthetic joint infection isolates. In contrast to our prior findings with staphylococcal biofilms, there was low antibiofilm activity of rifampin, rifabutin, and rifapentine against PJI-associated streptococci and enterococci, apart from some Streptococcus mitis group isolates. |
| Databáze: | OpenAIRE |
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