Expression of dendritic cell lysosome-associated membrane protein and dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin in condyloma acuminatum lesions
| Autor: | Wei-Yuan Ma, Qi-Chao Qi, Le Zhuang, Qing Sun |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Receptors Cell Surface Biology Biochemistry Genital warts Young Adult Lysosome medicine Humans Lectins C-Type Receptor Biochemistry (medical) Lysosome-Associated Membrane Glycoproteins Dendritic Cells Cell Biology General Medicine Dendritic cell Middle Aged Condyloma Acuminatum Intercellular adhesion molecule medicine.disease Immunohistochemistry Neoplasm Proteins medicine.anatomical_structure Membrane protein Condylomata Acuminata Cancer research Lysosomes Cell Adhesion Molecules |
| Zdroj: | Journal of International Medical Research. 41:138-145 |
| ISSN: | 1473-2300 0300-0605 |
| Popis: | Objective Retrospective, observational study to explore the role of dendritic cells (DCs) in condyloma acuminatum lesions (genital warts) and their relationship with duration of the disease. Methods Condyloma acuminatum lesion samples were collected from male patients with the condition and compared with normal foreskin samples from male volunteers. Cellular locations of dendritic cell lysosome-associated membrane protein (DC-LAMP) and dendritic cell-specific intercellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN) were detected using immunohistochemistry. Levels of both proteins were determined using Western blot analysis; levels of their corresponding mRNAs were measured using reverse transcription–polymerase chain reaction. Results The mRNA and protein levels of DC-LAMP and DC-SIGN were both significantly higher in condyloma acuminatum lesions ( n = 30 samples) compared with normal skin samples ( n = 13). Levels of DC-LAMP and DC-SIGN protein and duration of disease were inversely correlated. Conclusions DC-LAMP and DC-SIGN may be involved in the pathogenesis of condyloma acuminatum. Their levels were inversely correlated with the duration of disease, suggesting that DCs might be involved in human papillomavirus clearance. |
| Databáze: | OpenAIRE |
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