Two New Peltogynoids fromAcacia niloticaDelile with Kinase Inhibitory Activity
| Autor: | Alexios-Leandros Skaltsounis, François Tillequin, Agunu Abdulkarim, Vassilios Myrianthopoulos, Raphaël Grougnet, A. A. Ahmadu, Prokopios Magiatis |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Stereochemistry
Chemical structure Pharmaceutical Science Acacia Pharmacognosy Analytical Chemistry Triterpene Drug Discovery Botany Medicinal plants Protein Kinase Inhibitors Flavonoids Pharmacology chemistry.chemical_classification Cyclin-dependent kinase 1 Plant Stems biology Plant Extracts Kinase Organic Chemistry biology.organism_classification Enzyme Complementary and alternative medicine chemistry Plant Bark Molecular Medicine Protein Kinases |
| Zdroj: | Planta Medica. 76:458-460 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-0029-1186226 |
| Popis: | Two new peltogynoids, acanilol A ( 1) and acanilol B ( 2), were isolated from the stem bark of ACACIA NILOTICA (L.) Delile, together with the known triterpene lupenone. The structures of the new compounds were established on the basis of their spectral data, mainly UV, NMR, and mass spectrometry. The new compounds were tested as kinase inhibitors against CDK1, GSK3, CK1, and DYRK1A, and acanilol B was identified as a DYRK1A inhibitor, with an IC 50 of 19 μM. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|