Laparoscopic based renal denervation in a canine neurogenic hypertension model
| Autor: | Guang Rong, Ting Bo Jiang, Longsheng Lan, Longjiang Xu, Boxin Xue, Pieter R. Stella, Yan Zhou, Tao You, Chunlai Shao, Zhigang Miao, Yin |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty lcsh:Diseases of the circulatory (Cardiovascular) system Time Factors Urology Renal function Blood Pressure 030204 cardiovascular system & hematology Kidney Blood Urea Nitrogen 03 medical and health sciences chemistry.chemical_compound Norepinephrine 0302 clinical medicine Dogs Renal Artery medicine.artery medicine Animals 030212 general & internal medicine Renal artery Sympathectomy Blood urea nitrogen Denervation Creatinine business.industry Neurogenic hypertension Vagus Nerve Disease Models Animal medicine.anatomical_structure Blood pressure Hypertension canine model chemistry lcsh:RC666-701 Hypertension Renal denervation Laparoscopy Female Cardiology and Cardiovascular Medicine business Biomarkers Research Article Refractory hypertension |
| Zdroj: | BMC Cardiovascular Disorders BMC Cardiovascular Disorders, Vol 20, Iss 1, Pp 1-10 (2020) |
| ISSN: | 1471-2261 |
| Popis: | Background Previous renal denervation (RDN) studies showed controversial results in reducing blood pressure. The aim of this study was to provide evidence supporting the effectiveness of laparoscopic-based renal denervation (L-RDN) in treating hypertension. Methods Sixteen Beagle dogs were randomly divided into RDN group (n = 12) and sham group (n = 4). Neurogenic hypertension was generated in all dogs via carotid artery route. L-RDN was performed in the RDN group, with sham operation performed as a control. Blood pressure (BP) changes were recorded at 2, 4, 6, and 8 weeks after the procedure. Changes in serum creatinine (sCr), blood urea nitrogen (BUN) and level of norepinephrine (NE) were analyzed. Histological changes of kidney and renal arteries were also evaluated. Results BP and NE levels were significantly elevated after hypertension induction (p p p = 0.0021, respectively) at the eighth week after L-RDN. Invasive systolic and diastolic BP of RDN group were significantly decreased by 14.5 mmHg and 15.3 mmHg (p p Conclusions L-RDN lowered BP and NE levels in hypertensive dogs without affecting renal artery morphology and kidney function. |
| Databáze: | OpenAIRE |
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