Systemic and Ocular Findings in 100 Patients With Optic Nerve Hypoplasia
| Autor: | Edna B. Ty, A. David Rothner, Mehryar Taban, Douglas Rogers, Elias I. Traboulsi, M. Lourdes Garcia |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Pathology medicine.medical_specialty Visual acuity Adolescent genetic structures Developmental Disabilities Population Vision Disorders Endocrine System Diseases Corpus callosum Cerebral Ventricles Cerebral palsy 03 medical and health sciences 0302 clinical medicine Pregnancy 030225 pediatrics Optic Nerve Diseases medicine Humans Abnormalities Multiple Child education Retrospective Studies Optic nerve hypoplasia education.field_of_study Epilepsy business.industry Cerebral Palsy Infant Newborn Infant Optic Nerve Unilateral Optic Nerve Hypoplasia medicine.disease eye diseases Hydrocephalus Diabetes Gestational Fetal Alcohol Spectrum Disorders Dysplasia Child Preschool Pediatrics Perinatology and Child Health Female Septum Pellucidum Neurology (clinical) Agenesis of Corpus Callosum medicine.symptom business Infant Premature 030217 neurology & neurosurgery |
| Zdroj: | Journal of Child Neurology. 21:949-956 |
| ISSN: | 1708-8283 0883-0738 |
| DOI: | 10.1177/08830738060210111701 |
| Popis: | To describe associated ocular, neurologic, and systemic findings in a population of children with optic nerve hypoplasia, a retrospective chart review of 100 patients with optic nerve hypoplasia for the presence of neurologic, radiologic, and endocrine abnormalities was performed. Neuroimaging and endocrine studies were obtained in 65 cases. Visual acuity and associated ocular, neurologic, endocrine, systemic, and structural brain abnormalities were recorded. Seventy-five percent had bilateral optic nerve hypoplasia. Conditions previously associated with optic nerve hypoplasia and present in our patients include premature birth in 21%, fetal alcohol syndrome in 9%, maternal diabetes in 6%, and endocrine abnormalities in 6%. Developmental delay was present in 32%, cerebral palsy in 13%, and seizures in 12%. Of those imaged, 60% had an abnormal study. Neuroimaging showed abnormalities in ventricles or white- or gray-matter development in 29 patients, septo-optic dysplasia in 10, hydrocephalus in 10, and corpus callosum abnormalities in 8. There was an associated clinical neurologic abnormality in 57% of patients with bilateral optic nerve hypoplasia and in 32% of patients with unilateral optic nerve hypoplasia. Patients with unilateral and bilateral optic nerve hypoplasia frequently have a wide range and common occurrence of concomitant neurologic, endocrine, and systemic abnormalities. (J Child Neurol 2006;21:949—956; DOI 10.2310/7010.2006.00241). |
| Databáze: | OpenAIRE |
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