Antihistamines and production of granulocyte-macrophage colony-stimulating factor and interleukin-8 by human bronchial epithelial cells in vitro: Evaluation of the effects of loratadine and cetirizine
| Autor: | R. Aloui, C. Amsellem, Michel Lagarde, W. Czarlewski, F. Gormand, M. Melac, Y. Pacheco, R. Hosni, B. Guibert, M. Perrin-Fayolle |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_treatment Bronchi Enzyme-Linked Immunosorbent Assay Loratadine Epithelium chemistry.chemical_compound medicine Humans Interleukin 8 Cells Cultured Aged Pharmacology Tumor Necrosis Factor-alpha business.industry Interleukin-8 Granulocyte-Macrophage Colony-Stimulating Factor Middle Aged Cetirizine Granulocyte macrophage colony-stimulating factor Cytokine chemistry Immunology Histamine H1 Antagonists Female Antihistamine Tumor necrosis factor alpha business Histamine medicine.drug |
| Zdroj: | General Pharmacology: The Vascular System. 27:269-272 |
| ISSN: | 0306-3623 |
| DOI: | 10.1016/0306-3623(95)02009-8 |
| Popis: | 1. In this study, we compared the effects of two antihistamine drugs on the production of granulocyte-macrophage colony-stimulating factor and interleukin-8 by human bronchial epithelial cells in vitro. 2. Cytokine production was assessed by the use of an enzyme-linked immunosorbent assay. 3. Epithelial cells spontaneously released both cytokines and tumor necrosis factor alone induced a significant increase in this production but loratadine and cetirizine had no effect at the various concentrations studied. 4. The antihistamines have no effect and this suggests that histamine plays no role in cytokine production under these conditions. |
| Databáze: | OpenAIRE |
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