Secondary metabolites of petri-dish cultured Antrodia camphorata and their hepatoprotective activities against alcohol-induced liver injury in mice
| Autor: | Yu Wu, Ting Lin, Zu-Jian Liao, Shuo Gao, Pei-Hsin Lin, Xiang-Zhong Liu, Mi Zhou, De-Quan Zeng, Wen-Jing Tian, Guanghui Wang, Jir-Mehng Lo, Daren Qiu, Hai-Feng Chen |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Alcoholic liver disease Cholesterol VLDL Alcohol 01 natural sciences Terpene 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Malondialdehyde Drug Discovery medicine Animals Aspartate Aminotransferases Fruiting Bodies Fungal Antrodia Liver Diseases Alcoholic Triglycerides Liver injury Biological Products Traditional medicine Triglyceride biology Ethanol Molecular Structure 010405 organic chemistry Cholestenes Alanine Transaminase General Medicine Aldehyde Dehydrogenase medicine.disease biology.organism_classification Acute toxicity Triterpenes 0104 chemical sciences Disease Models Animal Complementary and alternative medicine chemistry Liver 030220 oncology & carcinogenesis Female Chemical and Drug Induced Liver Injury |
| Zdroj: | Chinese journal of natural medicines. 17(1) |
| ISSN: | 1875-5364 |
| Popis: | Antrodia camphorata, a well-known and highly valued edible medicinal mushroom with intriguing activities like liver protection, has been traditionally used for the treatment of alcoholic liver disease. A. camphorata shows highly medicinal and commercial values with the demand far exceeds the available supply. Thus, the petri-dish cultured A. camphorata (PDCA) is expected to develope as a substitute. In this paper, nineteen triterpenes were isolated from PDCA, and thirteen of them were the unique anthroic acids in A. camphorata, including the main content antcin K, which suggested that PDCA produced a large array of the same anthroic acids as the wild one. Furthermore, no obvious acute toxicity was found suggesting the edible safety of PDCA. In mice alcohol-induced liver injury model, triglyceride (TG), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and malondialdehyde (MDA) had been reduced by the PDCA powder as well as the main content antcin K, which indicated that the PDCA could protect alcoholic liver injury in mice model and antcin K could be the effective component responsible for the hepatoprotective activities of PDCA against alcoholic liver diseases. |
| Databáze: | OpenAIRE |
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