Rapidly Progressive Transthyretin-Mediated Amyloidosis in a Domino Liver Transplant Recipient of a Ser23Asn Donor
| Autor: | Rebecca Traub, Neel Dixit, Suzanne Lentzsch, Mathew S. Maurer, Thomas H. Brannagan, Mary Jane Farr, Robert S. Brown, Adam Castano |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment macromolecular substances Liver transplantation Gastroenterology Domino 03 medical and health sciences 0302 clinical medicine Internal medicine Serine medicine Humans Prealbumin In patient Amyloid Neuropathies Familial biology business.industry Amyloidosis liver Amyloidosis nutritional and metabolic diseases General Medicine medicine.disease Systemic amyloidosis Liver Transplantation Liver transplant recipient Transthyretin Treatment Outcome Neurology Mutation biology.protein 030211 gastroenterology & hepatology Neurology (clinical) Asparagine business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Clinical Neuromuscular Disease. 17:142-145 |
| ISSN: | 1522-0443 |
| DOI: | 10.1097/cnd.0000000000000110 |
| Popis: | Domino liver transplantation, in which the liver of a patient with transthyretin-mediated amyloidosis is transplanted into another patient, has been an established procedure performed at several centers across the world. The risk of developing systemic amyloidosis in transthyretin-mediated amyloidosis liver transplant recipients is a topic of ongoing investigation. We report a case of rapidly progressive transthyretin amyloidosis in a patient who received a liver from a donor with a rare Ser23Asn mutation. We advise exercising caution when considering domino liver transplantation in patients with this particular mutation. |
| Databáze: | OpenAIRE |
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