| Autor: |
Jeanna A. Bugaytsova, Kristof Moonens, Artem Piddubnyi, Alexej Schmidt, Johan Olofsson Edlund, Gennadii Lisiutin, Kristoffer Brännström, Yevgen A. Chernov, Kaisa Thorel, Iryna Tkachenko, Oleksandra Sharova, Iryna Vikhrova, Anna Butsyk, Pavlo Shubin, Ruslana Chyzhma, Daniel X. Johansson, Harold Marcotte, Rolf Sjöström, Anna Shevtsova, Göran Bylund, Lena Rakhimova, Anders Lundquist, Oleksandra Berhilevych, Victoria Kasianchuk, Andrii Loboda, Volodymyr Ivanytsia, Kjell Hultenby, Mats A. A. Persson, Joana Gomes, Rita Matos, Fátima Gartner, Celso A. Reis, Jeannette M. Whitmire, D. Scott Merrell, Qiang Pan-Hammarström, Maréne Landström, Stefan Oscarson, Mario M. D’Elios, Lars Agreus, Jukka Ronkainen, Pertti Aro, Lars Engstrand, David Y. Graham, Vladyslava Kachkovska, Asish Mukhopadhyay, Sujit Chaudhuri, Bipul Chandra Karmakar, Sangita Paul, Oleksandr Kravets, Margarita Camorlinga, Javier Torres, Douglas E. Berg, Roman Moskalenko, Rainer Haas, Han Remaut, Lennart Hammarström, Thomas Borén |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
bioRxiv |
| Popis: |
SUMMARYThe majority of the world population carry the gastric pathogenHelicobacter pylori. Fortunately, most individuals experience only low-grade or no symptoms, but in many cases the chronic inflammatory infection develops into severe gastric disease, including duodenal ulcer disease and gastric cancer. Here we report on a protective mechanism whereH. pyloriattachment and accompanying chronic mucosal inflammation can be reduced by antibodies that are present in a vast majority ofH. pyloricarriers. These antibodies block binding of theH. pyloriattachment protein BabA by mimicking BabA’s binding to the ABO blood group glycans in the gastric mucosa. However, many individuals demonstrate low titers of BabA blocking antibodies, which is associated with an increased risk for duodenal ulceration, suggesting a role for these antibodies in preventing gastric disease. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
