Growth in patients with isolated gonadotrophin deficiency
Autor: | Z Dickerman, A Cohen, Zvi Laron |
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Rok vydání: | 1992 |
Předmět: |
Adult
Male medicine.medical_specialty Time Factors Adolescent Physiology Epiphyseal closure Sex hormone-binding globulin Internal medicine Medicine Humans In patient Testosterone Child Growth Disorders Retrospective Studies biology Estradiol business.industry Significant difference Final height Puberty Age Factors Infant Chronological age Body Height Gonadotrophin deficiency Endocrinology Child Preschool Pediatrics Perinatology and Child Health biology.protein Female business Gonadotropins Research Article |
Zdroj: | Archives of disease in childhood. 67(4) |
ISSN: | 1468-2044 |
Popis: | The growth pattern of 66 patients (50 males, 16 females) with isolated gonadotrophin deficiency (IGnD), who had reached their final height with epiphyseal closure, was evaluated. For the purpose of analysis the males were divided into two groups according to age at referral: group 1 less than 16 years (n = 23) and group 2 greater than or equal to 16 years (n = 27). Sex hormone treatment was initiated at a mean (SD) chronological age of 15.8 (1.3) and 18.6 (1.2) years in groups 1 and 2 in the males and at 15.3 (1.3) years in the females. The duration of treatment (until epiphyseal closure) in the males was 3.9 (1.5) years in group 1 and 2.1 (1.0) years in group 2 and 2.8 (1.3) years in the females. There was no significant difference between the mean final height in groups 1 and 2, but it was significantly higher than the mean parental height (mean height SD score (HtSDS): 0.1 (1.1) v -0.8 (0.9)) and they were significantly correlated. For females the mean HtSDS compared with parental height was 0.4 (1.5) v -0.6 (1.2). It is concluded that the timing of induction of puberty by sex hormones in males and females with IGnD has no significant effect on final height provided that moderate doses are used. Furthermore final height was significantly correlated to mid-parental height. |
Databáze: | OpenAIRE |
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