Mitochondrial involvement in chronic chagasic cardiomyopathy
| Autor: | María Silvina Lo Presti, Alejandra Baez, Patricia Pons, Patricia A. Paglini-Oliva, Ricardo Fretes, Héctor Walter Rivarola, Gustavo Guzmán Mentesana |
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| Rok vydání: | 2010 |
| Předmět: |
Chagas disease
Chagas Cardiomyopathy Male Trypanosoma cruzi Cell Respiration Cardiomyopathy Respiratory chain Mitochondrion Mitochondria Heart Pathogenesis Mice parasitic diseases medicine Citrate synthase Animals Muscle Skeletal biology Public Health Environmental and Occupational Health Skeletal muscle Heart General Medicine medicine.disease biology.organism_classification Survival Rate Infectious Diseases medicine.anatomical_structure Immunology Chronic Disease biology.protein Disease Progression Parasitology Female |
| Zdroj: | Transactions of the Royal Society of Tropical Medicine and Hygiene. 105(5) |
| ISSN: | 1878-3503 |
| Popis: | The pathogenesis of chronic chagasic cardiopathy is still under discussion; there is considerable evidence that inflammatory infiltrates and their mediators have a direct effect on cardiac cells. Here we studied the structure and function of cardiac mitochondria in chronic chagasic myocardiopathy. Cardiac mitochondrial structure and enzyme activity of citrate synthase and complexes I to IV of the respiratory chain were studied in albino Swiss mice infected with Trypanosoma cruzi (Tulahuen strain or SGO Z12 isolate) on 365 days post-infection (dpi). The presence of parasites in cardiac and skeletal muscle was also investigated. The activity of complexes I to IV was altered in different ways, according to the strain employed (P0.0001), in relation to the cristae disorganisation and the parasite persistence found in the Tulahuen group, and the chronic inflammatory process described in both groups; citrate synthase activity also increased in both infected groups. Changes in mitochondrial structure were detected in 89% of Tulahuen- and 58% of SGO Z12-infected mice. In this paper we demonstrate that parasite persistence and inflammation are likely to be involved in the structural and functional alterations in cardiac mitochondria from chronically T. cruzi-infected mice, demonstrating that the parasite strain determines different mitochondrial changes in chagasic cardiopathy. |
| Databáze: | OpenAIRE |
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