Decreased functional connectivity of the insula within the salience network as an indicator for prospective insufficient response to antidepressants
| Autor: | D.J. Veltman, Brenda W.J.H. Penninx, Henricus G. Ruhé, Hanneke Geugies, Lianne Schmaal, Caroline A. Figueroa, Esther M. Opmeer, Jan-Bernard C Marsman, Robert A. Schoevers, N.J.A. van der Wee, André Aleman, M.J.D. van Tol |
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| Přispěvatelé: | Academic Medical Center, Perceptual and Cognitive Neuroscience (PCN), Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Clinical Neuropsychology, Clinical Cognitive Neuropsychiatry Research Program (CCNP), Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Psychiatry, APH - Mental Health, Anatomy and neurosciences, APH - Digital Health |
| Rok vydání: | 2019 |
| Předmět: |
Male
Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] TPN task positive network Insula MDD major depressive disorder Brain mapping lcsh:RC346-429 0302 clinical medicine IDS Inventory of Depressive Symptomatology Insufficient antidepressant response Medicine CIDI Composite Interview Diagnostic Instrument NESDA Netherlands Study on Depression and Anxiety Cerebral Cortex Brain Mapping Depression Functional connectivity ACC anterior cingulate cortex 05 social sciences fMRI Regular Article Middle Aged Magnetic Resonance Imaging ICA independent component analysis Antidepressive Agents Treatment Outcome Neurology DLPFC dorsolateral prefrontal cortex Major depressive disorder Antidepressant Anxiety lcsh:R858-859.7 Female medicine.symptom psychological phenomena and processes RS-FC Resting-state functional connectivity BAI Beck Anxiety Inventory Adult medicine.medical_specialty TRD treatment resistant depression Cognitive Neuroscience lcsh:Computer applications to medicine. Medical informatics behavioral disciplines and activities 050105 experimental psychology Salience 03 medical and health sciences All institutes and research themes of the Radboud University Medical Center Physical medicine and rehabilitation SVC small volume correction Salience (neuroscience) Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging AD antidepressants MPFC medial prefrontal cortex lcsh:Neurology. Diseases of the nervous system Depressive Disorder Major Resting state fMRI business.industry medicine.disease PCC posterior cingulate cortex CCN cognitive control network DMN default mode network Resting state functional connectivity Neurology (clinical) Nerve Net business 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | NeuroImage : Clinical NeuroImage: Clinical, Vol 24, Iss, Pp-(2019) NeuroImage. Clinical, 24:102064. Elsevier BV NeuroImage: Clinical Neuroimage. Clinical, 24 NeuroImage. Clinical, 24:102064. ELSEVIER SCI LTD NeuroImage: Clinical, 24. ELSEVIER SCI LTD Geugies, H, Opmeer, E M, Marsman, J B C, Figueroa, C A, van Tol, M J, Schmaal, L, van der Wee, N J A, Aleman, A, Penninx, B W J H, Veltman, D J, Schoevers, R A & Ruhé, H G 2019, ' Decreased functional connectivity of the insula within the salience network as an indicator for prospective insufficient response to antidepressants ', NeuroImage: Clinical, vol. 24, 102064 . https://doi.org/10.1016/j.nicl.2019.102064 NeuroImage: Clinical, 24:102064. Elsevier BV |
| ISSN: | 2213-1582 |
| DOI: | 10.1016/j.nicl.2019.102064 |
| Popis: | Highlights • Connectivity analyses complemented with a metric exploring switching in brain activity. • Lower insula-salience connectivity predicts insufficient antidepressant response. • This same insula region is activated less when switching from task to a rest. • This could be a potential biomarkers for predicting future antidepressant response. Insufficient response to treatment is the main cause of prolonged suffering from major depressive disorder (MDD). Early identification of insufficient response could result in faster and more targeted treatment strategies to reduce suffering. We therefore explored whether baseline alterations within and between resting state functional connectivity networks could serve as markers of insufficient response to antidepressant treatment in two years of follow-up. We selected MDD patients (N = 17) from the NEtherlands Study of Depression and Anxiety (NESDA), who received ≥ two antidepressants, indicative for insufficient response, during the two year follow-up, a group of MDD patients who received only one antidepressant (N = 32) and a healthy control group (N = 19) matched on clinical characteristics and demographics. An independent component analysis (ICA) of baseline resting-state scans was conducted after which functional connectivity within the components was compared between groups. We observed lower connectivity of the right insula within the salience network in the group with ≥ two antidepressants compared to the group with one antidepressant. No difference in connectivity was found between the patient groups and healthy control group. Given the suggested role of the right insula in switching between task-positive mode (activation during attention-demanding tasks) and task-negative mode (activation during the absence of any task), we explored whether right insula activation differed during switching between these two modes. We observed that in the ≥2 antidepressant group, the right insula was less active compared to the group with one antidepressant, when switching from task-positive to task-negative mode than the other way around. These findings imply that lower right insula connectivity within the salience network may serve as an indicator for prospective insufficient response to antidepressants. This result, supplemented by the diminished insula activation when switching between task and rest related networks, could indicate an underlying mechanism that, if not sufficiently targeted by current antidepressants, could lead to insufficient response. When replicated, these findings may contribute to the identification of biomarkers for early detection of insufficient response. |
| Databáze: | OpenAIRE |
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