Onchocerciasis-associated epilepsy: From recent epidemiological and clinical findings to policy implications
| Autor: | Pierre-Marie Preux, Nolbert Gumisiriza, Jean Marie Kashama, Robert Colebunders, Deby Mukendi, Michel Mandro, Alfred K. Njamnshi, Patrick Suykerbuyk, Marieke van Oijen, Richard Idro |
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| Přispěvatelé: | University of Antwerp ( UA ), Neuroépidémiologie Tropicale ( NET ), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique ( GEIST ), Université de Limoges ( UNILIM ) -Université de Limoges ( UNILIM ) -CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service de l'Information Médicale et de l'Évaluation [CHU Limoges] ( SIME ), CHU Limoges, Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges ( UNILIM ), University of Antwerp (UA), Neuroépidémiologie Tropicale (NET), CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), Service de l'Information Médicale et de l'Évaluation [CHU Limoges] (SIME), Université de Limoges (UNILIM), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Rok vydání: | 2017 |
| Předmět: |
Burden of disease
medicine.medical_specialty Pediatrics Nodding syndrome 030231 tropical medicine Nakalanga syndrome 03 medical and health sciences Epilepsy 0302 clinical medicine Epidemiology medicine Prevalence 030212 general & internal medicine Psychiatry Critical Reviews ComputingMilieux_MISCELLANEOUS Ivermectin Nodding Syndrome business.industry Incidence (epidemiology) Public health Incidence [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie Critical Review medicine.disease 3. Good health Neurology [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie Neurology (clinical) Onchocerciasis business |
| Zdroj: | Epilepsia Open Epilepsia Open, 2017, 2 (2), pp.1-8. 〈10.1002/epi4.12054〉 Epilepsia Open, 2017, 2 (2), pp.1-8. ⟨10.1002/epi4.12054⟩ |
| ISSN: | 2470-9239 |
| DOI: | 10.1002/epi4.12054 |
| Popis: | Summary A high prevalence of epilepsy is reported in many onchocerciasis‐endemic regions. In this paper we discuss recent epidemiological and clinical aspects as well as public health implications of onchocerciasis‐associated epilepsy (OAE) and propose a strategy to reduce the burden of disease. OAE probably presents in a variety of clinical manifestations, including the nodding syndrome and the Nakalanga syndrome. The most common clinical presentation, however, is generalized (primarily tonic‐clonic) seizures. A characteristic of OAE is the onset of seizures between the ages of 3 and 18 years and clustering in certain families and villages close to rapid‐flowing black‐fly‐infested rivers. A strategy combining active surveillance for epilepsy with early treatment with antiepileptic drugs and prevention of onchocerciasis by increasing the geographical and therapeutic coverage of community‐directed treatment with ivermectin (CDTi) may considerably decrease the burden of disease. |
| Databáze: | OpenAIRE |
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