Oncogenic miRNA-1908 targets HDAC10 and promotes the aggressive phenotype of cervical cancer cell
| Autor: | Dong-Sheng Yu, Xiao-Lei Song, Chao Yan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Medicine (General)
cervical cancer miR‐1908 Down-Regulation Uterine Cervical Neoplasms medicine.disease_cause Histone Deacetylases 03 medical and health sciences 0302 clinical medicine R5-920 Downregulation and upregulation Cell Line Tumor microRNA medicine HDAC10 Humans Neoplasm Invasiveness 3' Untranslated Regions Cell Proliferation Cervical cancer Cell growth business.industry Cancer Computational Biology General Medicine medicine.disease invasion MicroRNAs Phenotype 030220 oncology & carcinogenesis Cancer research 030211 gastroenterology & hepatology Ectopic expression Female Carcinogenesis business Plasmids Protein Binding |
| Zdroj: | Kaohsiung Journal of Medical Sciences, Vol 37, Iss 5, Pp 402-410 (2021) |
| ISSN: | 2410-8650 |
| Popis: | MicroRNAs (miRNAs) have vital functions in tumorigenesis and cancer progression. The significance of miR‐1908 in cervical cancer has not been determined. We revealed that miR‐1908 was notably upregulated in cervical cancer. Upregulation of miR‐1908 increased cervical carcinoma cell growth and invasion. Downregulation of miR‐1908 caused the opposite effects. We confirmed that histone deacetylase 10 (HDAC10) was a potential target of miR‐1908 using bioinformatics analysis and luciferase reporter gene assays. Western blot analysis showed that miR‐1908 regulated the expression of HDAC10 by binding its 3′‐UTR. In addition, ectopic expression of HDAC10 partially reversed the promoting effects of miR‐1908. In conclusion, our findings indicated that miR‐1908 targets HDAC10 in cervical cancer and regulates aggressive cervical cancer cell phenotypes. |
| Databáze: | OpenAIRE |
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