Gastrointestinal side effects of orlistat may be prevented by concomitant prescription of natural fibers (psyllium mucilloid)
| Autor: | Geraldo Medeiros-Neto, I Floriano, H. Cavaliere |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
medicine.medical_specialty Endocrinology Diabetes and Metabolism Medicine (miscellaneous) Blood lipids Placebo Gastroenterology Psyllium Lactones Internal medicine medicine Humans Obesity Orlistat Cross-Over Studies Nutrition and Dietetics business.industry Gastrointestinal Lipase Inhibitor Crossover study Endocrinology Concomitant Female Anti-Obesity Agents business Digestive System Body mass index medicine.drug |
| Zdroj: | International Journal of Obesity. 25:1095-1099 |
| ISSN: | 1476-5497 0307-0565 |
| DOI: | 10.1038/sj.ijo.0801645 |
| Popis: | OBJECTIVES: This placebo-controlled open study was designed to test the hypothesis that most of the gastrointestinal (GI) side events induced by treatment of obese patients with orlistat (a gastrointestinal lipase inhibitor) could be prevented or ameliorated by concomitant use of natural fibers (psyllium mucilloid). DESIGN: Two groups of obese women (BMI>27 kg/m2) were treated with orlistat 120 mg three times a day. One group (A, n=30) was randomized to receive orlistat and, approximately 6.0 g of orange-flavored psyllium mucilloid dissolved in water and the other group (B, n=30) received orlistat and orange-flavored placebo. At the end of 30 days and 2 weeks of washout, group A switched to placebo and group B received psyllium while continuing orlistat three times a day. SUBJECTS: Sixty professional women, more than 21-y-old with a body mass index (BMI) between 27.3 and 48.0 kg/m2, who were not receiving any other medication. MEASUREMENTS: Assessments included weekly visits to attending physician, filling a form in which GI events were recorded, monthly measurements of body weight, blood pressure and serum lipids. The frequency and severity of GI events were evaluated by a score system, based on information provided by the patients. RESULTS: Both groups A and B significantly lost (P |
| Databáze: | OpenAIRE |
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