The Role of Histone Acetylation-/Methylation-Mediated Apoptotic Gene Regulation in Hepatocellular Carcinoma

Autor: Mathew Schade, Zijian Xie, Juan D Sanabria, Sandrine V. Pierre, Utibe-Abasi Udoh, Moumita Banerjee, Joseph I. Shapiro, Jacqueline A Sanabria, Gary Smith, Juan Sanabria, Pradeep K Rajan, Komal Sodhi
Rok vydání: 2020
Předmět:
0301 basic medicine
Carcinoma
Hepatocellular
Apoptosis
Review
Catalysis
Histones
lcsh:Chemistry
Inorganic Chemistry
03 medical and health sciences
0302 clinical medicine
NAFLD
Histone methylation
medicine
Humans
histone modification
histone methylation
Epigenetics
HCC
Physical and Theoretical Chemistry
lcsh:QH301-705.5
Molecular Biology
Gene
Spectroscopy
biology
Liver Neoplasms
Organic Chemistry
histone acetylation
NASH
Acetylation
General Medicine
Methylation
DNA Methylation
medicine.disease
digestive system diseases
Computer Science Applications
Gene Expression Regulation
Neoplastic
030104 developmental biology
Histone
lcsh:Biology (General)
lcsh:QD1-999
Drug development
030220 oncology & carcinogenesis
Hepatocellular carcinoma
Cancer research
biology.protein
Protein Processing
Post-Translational
Zdroj: International Journal of Molecular Sciences, Vol 21, Iss 8894, p 8894 (2020)
International Journal of Molecular Sciences
ISSN: 1422-0067
Popis: Epigenetics, an inheritable phenomenon, which influences the expression of gene without altering the DNA sequence, offers a new perspective on the pathogenesis of hepatocellular carcinoma (HCC). Nonalcoholic steatohepatitis (NASH) is projected to account for a significant share of HCC incidence due to the growing prevalence of various metabolic disorders. One of the major molecular mechanisms involved in epigenetic regulation, post-translational histone modification seems to coordinate various aspects of NASH which will further progress to HCC. Mounting evidence suggests that the orchestrated events of cellular and nuclear changes during apoptosis can be regulated by histone modifications. This review focuses on the current advances in the study of acetylation-/methylation-mediated histone modification in apoptosis and the implication of these epigenetic regulations in HCC. The reversibility of epigenetic alterations and the agents that can target these alterations offers novel therapeutic approaches and strategies for drug development. Further molecular mechanistic studies are required to enhance information governing these epigenetic modulators, which will facilitate the design of more effective diagnosis and treatment options.
Databáze: OpenAIRE
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