Genetic Background and Allorecognition Phenotype in Hydractinia symbiolongicarpus
| Autor: | Anahid E. Powell, Stephen L. Dellaporta, Fadi G. Lakkis, Andrea Gloria-Soria, Leo W. Buss, María Ángeles Moreno |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Genetics
Investigation 0303 health sciences invertebrate immunity biology Haplotype Congenic hydroid biology.organism_classification Hydractinia symbiolongicarpus Phenotype Arc (geometry) 03 medical and health sciences 0302 clinical medicine Inbred strain Hydractinia recognition Allorecognition cnidarian Molecular Biology 030217 neurology & neurosurgery Genetics (clinical) 030304 developmental biology |
| Zdroj: | G3: Genes|Genomes|Genetics |
| ISSN: | 2160-1836 |
| Popis: | The Hydractinia allorecognition complex (ARC) was initially identified as a single chromosomal interval using inbred and congenic lines. The production of defined lines necessarily homogenizes genetic background and thus may be expected to obscure the effects of unlinked allorecognition loci should they exist. Here, we report the results of crosses in which inbred lines were out-crossed to wild-type animals in an attempt to identify dominant, codominant, or incompletely dominant modifiers of allorecognition. A claim for the existence of modifiers unlinked to ARC was rejected for three different genetic backgrounds. Estimates of the genetic map distance of ARC in two wild-type haplotypes differed markedly from one another and from that measured in congenic lines. These results suggest that additional allodeterminants exist in the Hydractinia ARC. |
| Databáze: | OpenAIRE |
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