Enhancing in vitro dissolution and in vivo bioavailability of fenofibrate by solid self-emulsifying matrix combined with SBA-15 mesoporous silica
| Autor: | Chuanbin Wu, Chan Zhou, Ge Li, Bao Chen, Zhengwen Zhan, Guilan Quan, Zhang Zhengzan, Xiaoxu Zhang, Qiaoli Wu, Xin Pan |
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| Rok vydání: | 2016 |
| Předmět: |
Materials science
Metabolic Clearance Rate Administration Oral Biological Availability Nanotechnology 02 engineering and technology 030226 pharmacology & pharmacy Matrix (chemical analysis) 03 medical and health sciences Dogs 0302 clinical medicine Colloid and Surface Chemistry Fenofibrate X-Ray Diffraction Pulmonary surfactant Animals Microemulsion Physical and Theoretical Chemistry Hypolipidemic Agents Surfaces and Interfaces General Medicine Mesoporous silica Poloxamer Silicon Dioxide 021001 nanoscience & nanotechnology Amorphous solid Bioavailability Drug Liberation Chemical engineering Area Under Curve Emulsifying Agents Microscopy Electron Scanning Emulsions Absorption (chemistry) 0210 nano-technology Porosity Biotechnology |
| Zdroj: | Colloids and Surfaces B: Biointerfaces. 141:476-482 |
| ISSN: | 0927-7765 |
| DOI: | 10.1016/j.colsurfb.2016.02.013 |
| Popis: | Mesoporous silica Santa Barbara amorphous-15 (SBA-15), derived from supermolecular assemblies of surfactant Pluronic(®) P123 with well-ordered 2-D hexagonal pores, was investigated as a reservoir to construct a novel solid self-emulsifying matrix for enhancing the oral bioavailability of fenofibrate (FNB). The emulsification rate and droplet size of a liquid self-emulsifying delivery system (SEDDS) were analyzed for optimization. SBA-15 was then added to the ethanol solution containing liquid SEDDS, and the obtained suspension changed into solid SEDDS matrix via solvent evaporation. The characterizations by SEM and XRD revealed that the solid matrix consisted of particles with smooth surface and FNB was completely transformed into molecular or amorphous state in the formulation. When introduced to aqueous media under gentle agitation, the solid matrix exhibited excellent self-emulsification properties and formed a uniform microemulsion with mean diameter of 117.35 ± 2.33 nm. The solid SEDDS matrix showed faster in vitro release rate than the raw powder and commercial capsule. The absorption of FNB delivered by solid SEDDS matrix was significantly improved in beagle dogs, and its Cmax and AUC values were about 8- and 4-fold greater than those of commercial products, respectively. In conclusion, SBA-15 emerged as a promising reservoir for SEDDS to enhance the bioavailability of poorly water-soluble drugs, which may provide a new strategy for advanced therapies. |
| Databáze: | OpenAIRE |
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